日本語
College of Pharmaceutical Sciences  /
Departmnent of Pharmaceutical Sciences

 (Male)
 Tatsuyuki   TAKADA  Professor

■Concurrent affiliation
Research Organization of Science and Technology   /
The Bio Medical Devices Center
Research Organization of Science and Technology   /
Research Center for Drug Discovery and Development Scieces
Graduate School of Life Sciences
Graduate School of Pharmacy
■Graduate school/University/other
03/1988  Tohoku University  "Graduate School, Division of Agriculture"
■Academic society memberships
The Molecular Biology Society of Japan  
International Society for Stem Cell Research  
■Subject of research
Differentiation control of pluripotent stem cells
Elucidation of the mechanism of environmental chemicals on cell differentiation
Preservation of endemic species in Lake Biwa using stem cell biology
Molecular cell biology in endemic species
■Research summary
Differentiation control of pluripotent stem cells and its application in pharmaceutical sciences

 I am focusing on the differentiation mechanism of pluripotent stem cells such as ES, iPS cells and germ stem cells with primary emphasis on the establishment of the methods to control their differentiation. My research also includes validation of natural compounds and synthetic chemicals on cell differentiation and carcinogenesis using genetically engineered stem cells. Recent data suggest that adipocyte differentiation can be switched to osteoblast simply using siRNA. This method can be applied for the treatment and prevention of osteoporosis. In addition, we found that environmental chemicals modulate germ cell differentiation and retinoic acid signaling in ES cells. I am also interested in application of stem cell biology towards preservation of endemic species of lake Biwa which is the 3rd-oldest lake in the world. We succeeded to establish cell line from endemic fish (Honmoroko, Gnathopogon caerulescens) and to differentiate functional sperm from spermatogonia in vitro.
■Research keywords
Stem cells, pluripotency, differentiation, biotechnology, environment, endemic species 
■Research activities   (Even top three results are displayed. In View details, all results for public presentation are displayed.)

Books
遺伝子発現の制御を測定する新手法  岡本誉士典、高田達之  化学  12-17  07/2016
多機能細胞から脂肪細胞への運命決定メカニズム  The lipid, 19, 13-18 (2008)  13-18  2008
カニクイザルES細胞とその遺伝子改変ザル作製への利用  バイオインダストリー  2,17-23  2005
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Papers
DNA methylation dynamics in
mouse preimplantation embryos
revealed by mass spectrometry  Yoshinori Okamoto, Naoko Yoshida, Toru Suzuki, Nobuhiro Shimozawa, Maki Asami, Tomonari Matsuda, Nakao Kojima, Anthony C. F. Perry & Tatsuyuki Takada  Sci. Rep.  6:19134  01/2016  10.1038/srep19134
Development and characterization of an embryonic cell line from endangered endemic cyprinid Honmoroko Gnathopogon caerulescens (Sauvage, 1883)  Higaki S., Shimada M., Koyama Y., Fujioka Y., Sakai N., Takada T.  In Vitro Cell Dev Biol Anim.  51, 763-768  2015  10.1007/s11626-015-9894-y
Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats  Okamoto Y, Tobe T, Ueda K, Takada T, Kojima N  J. Toxicol. Sci.  40/ 2, 235-242  2015  10.2131/jts.40.235
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Research presentations
琵琶湖固有魚のin vitro精子分化系を用いた化学物質の影響解析  第19回日本内分泌撹乱化学物質学会  12/08/2016
琵琶湖固有種ホンモロコ(Gnathopogon caerulescens)における雌雄生殖細胞低温保存の試み  第109回日本繁殖生物学会  09/12/2016
マウス初期胚におけるDNAメチル化動態の定量解析  第109回日本繁殖生物学会  09/12/2016
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Grants-in-Aid for Scientific Research (KAKENHI)
Link to Grants-in-Aid for Scientific Research -KAKENHI-

Competitive grants, etc. (exc. KAKENHI)
ES, iPS細胞を用いた環境バイオセンサーの開発  科学技術振興機構 地域イノベーション創出総合支援事業 重点地域研究開発推進プログラム 平成21年度「シーズ発掘試験A(発掘型)」  2009  2009  Main representative
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Intellectual property rights
タモロコ属魚類精子の受精能の評価方法  2014-20931  日本
モロコ細胞株・その製造方法及び用途  2011-129549  日本
遺伝子中のメチル化塩基の迅速・超高感度分析法  2011-102765  日本
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■Teaching experience   (Even top three results are displayed. In View details, all results for public presentation are displayed.)

Courses taught
2014  Biochemistry Laboratory 1  Laboratory work / Practical experience / Skills practice
2014  Biological Science 1  Lecture
2014  Life Science and Ethics  Lecture
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Teaching achievements
立命館慶祥高校「SSH立命館大学BKC研究室訪問」を担当した。  10/2015-10/2015
キャリア形成セミナー:
薬剤師としての、ビジョン形成、モチベーション向上のため、学外から講師を招き、セミナーを行い、その後、学生が気軽に質問、相談できるように軽食を取りながらの懇親会を企画実行した。  12/2010-
基礎専門科目「生物科学II」で理解することを最重要視し、詳しい解説をベースとした対話型講義を試みている。  10/2009-
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■Research keywords(on a multiple-choice system)
Applied molecular and cellular biology
Developmental Biology
Applied Genome Science
Risk sciences of radiation and chemicals
Biological System Pharmaceutical Science