日本語
College of Life Sciences  /
Department of Biotechnology

 (Male)
 Hisaaki   MIHARA  Professor

■Concurrent affiliation
Graduate School of Life Sciences
■Graduate school/University/other
03/1993  Kyoto Prefectural University  Faculty of Agriculture  Department of Agricultural Chemistry  Graduated
03/1995  Kyoto University  "Graduate School, Division of Agriculture"  Agricultural Chemistry Major   Master's course  Completed
03/1999  Kyoto University  "Graduate School, Division of Agriculture"  Agricultural Chemistry Major   Doctoral course second term (Doctoral)  Withdrawal from program with completion of credit requirements
■Academic degrees
Ph.D. (Agriculture) (09/1999 Kyoto University)  
■Career history
04/1997-03/1999  日本学術振興会特別研究員(DC2)
04/1999-03/2000  京都大学化学研究所非常勤研究員
04/2000-03/2007  京都大学化学研究所助手
04/2007-03/2009  京都大学化学研究所助教
04/2009-03/2014  Associate Professor, College of Life Sciences, Ritsumeikan University
04/2014-  Professor, College of Life Sciences, Ritsumeikan University
■Committee history
05/2013-  滋賀バイオ産業推進機構  バイオ・プロジェクト創出サロン事業運営委員
04/2014-  日本生化学会  評議員
04/2014-  日本農芸化学会関西支部  参与
04/2014-  日本微量栄養素学会  評議員
04/2014-  メタロミクス研究フォーラム  評議員
10/2014-  日本生物高分子学会  評議員
11/2015-10/2019  日本ビタミン学会  代議員
11/2015-11/2019  日本生化学会  代議員
04/2016-  日本微量栄養素学会  監事
10/2017-09/2019  日本生化学会近畿支部  庶務幹事
04/2018-03/2020  ビタミンB研究委員会  準委員
04/2018-  日本生化学会  Advisory Board
04/2018-  日本生物高分子学会  理事
01/2019-12/2020  日本生化学会  「生化学」誌企画委員
■Academic society memberships
The Japanese Biochemical Society  
"Japan Society for Bioscience, Biotechnology, and Agrochemistry "  
THE VITAMIN SOCIETY OF JAPAN  
Japan Society for Biomedica1 Research on Trace Elements  
Japan Trace Nutrients Research Society  
日本生物高分子学会  
■Subject of research
Structure and function of enzymes involved in trace element/metal metabolism
Production of useful chiral compounds with microbial enzymes
■Research summary
Analysis of structural functions of microorganisms and enzyme that are involved in the metabolism of metals and microelements, and application to the environmental cleanup, resource recovery and useful substance production

 I analyze microelements, particularly enzymes that are involved in the metabolism of selenium and aim to apply their functions to the environmental cleanup and substance production. In addition, I establish a new production system of chiral compound useful for the industry using microbial enzymes.
■Research keywords
enzyme, trace element, selenium, sulfur, selenoprotein, metal, microbe, chiral compound, bacteria, protein, cofactor, coenzyme, vitamin 
■Research activities   (Even top three results are displayed. In View details, all results for public presentation are displayed.)

Books
エッセンシャル タンパク質工学  老川典夫、大島敏久、保川清、三原久明、宮原郁子  講談社  02/2018
Selenium in Plants  Ryuta Tobe and Hisaaki Mihara  Springer  79-108  2017
Selenium: Its Molecular Biology and Role in Human and Health 4th Ed.  Mihara, H., Tobe, R., and Esaki, N.  Springer  113-123  09/2016
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Papers
毒か?栄養素か? 必須微量元素セレンの生物学  三原久明  海洋科学研究  31/ 2, 95-100  11/2018
Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis  Tobe, R., Mihara, H.  Biochim Biophys Acta  1862/ 11, 2433-2440  06/2018
Characterization of a Novel Porin-Like Protein, ExtI, from Geobacter sulfurreducens and Its Implication in the Reduction of Selenite and Tellurite  Jahan, M. I.
Tobe, R.
Mihara, H.  Int J Mol Sci  19/ 3, 809  03/2018  10.3390/ijms19030809
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Research presentations
Bacillus属細菌におけるテルル酸還元酵素の解析  メタルバイオサイエンス研究会2018  11/17/2018
Cellulomonas sp. D3a 株の亜セレン酸還元機構の解析  第6回メタロミクス研究フォーラム  11/02/2018
Pseudomonas putidaのD-リジン異化代謝オペロン転写制御因子の解析  第454回ビタミンB研究協議会  10/20/2018
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Grants-in-Aid for Scientific Research (KAKENHI)
Link to Grants-in-Aid for Scientific Research -KAKENHI-

Academic awards
 日本生化学会奨励賞  2010
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Intellectual property rights
アルカリ土類金属の炭酸塩の可溶化方法、可溶化剤及び新規微生物  2011-169162
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■Teaching experience   (Even top three results are displayed. In View details, all results for public presentation are displayed.)

Courses taught
2017  Experiments in Microbiology  Laboratory work / Practical experience / Skills practice
2017  Experiments in Molecular Biology  Laboratory work / Practical experience / Skills practice
2017  Seminar in Biotechnology  Seminar
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Teaching achievements
立命館慶祥高校「R-Navigation(高1・2対象学部ガイダンス)」を担当した。  12/2015-12/2015
立命館慶祥高校「アカデミック・ナビゲーション・ディ」を担当。  12/2015-12/2015
立命館宇治高校「キャリアナビ+R Ⅱ」を担当。  10/2015-10/2015
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■URL
 Laboratory of Applied Molecular Microbiology (Mihara Lab.)
■Tel
077-561-2732
■E-mail
■Research keywords(on a multiple-choice system)
Bio-related chemistry
Biofunction/Bioprocess
Structural Biochemistry
Functional Biochemistry
Applied Microbiology
Applied Biochemistry
Biological Production Chemistry/Biological Organic Chemistry