Researcher Database

（Last updated : 2024-02-23 12:47:28）　

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MUKAI ERI

Department / Course College of Life Sciences Department of Biomedical Sciences

Title / Position Professor

Other Affiliations
1.	Graduate School of Life Sciences

Academic background
1.	～2001/03	Doctorial Course │ Graduate School, Division of Medicine │ Kyoto University │ Completed Ph.D. in Medicine
2.	～1997/03	Master Course │ Human and Environmental Studies Major │ Graduate School, Division of Human and Environmental Studies │ Kyoto University │ Completed Master of Human and Environmental Studies
3.	～1995/03	Department of Agricultural Chemistry │ Department of Agriculture │ Kyoto Prefectural University │ Graduated

Business career
1.	2022/04 ～	Professor │ │

Research activities
1.		Japan Society of Nutrition and Food Science
2.		Physiological Society of Japan
3.		Japan Society of Experimental Diabetes and Obesity
4.		The Japan Diabetes Society
5.		Japan Society of Metabolism and Clinical Nutrition

Subject of research
1.	Study for Clinical Condition Elucidation and Treatment of Diabetes

Research summary
Today, with the developments in medicine made through the affluence in society, life-style related diseases caused by nutrition factors, such as over-nutrition and bias in palatability or from environmental causes, like the lack of exercise from the development of transportation, are steadily increasing annually. About 5 to 6% of the global adult population has type II diabetes, one of the typical life-style related diseases which is becoming a serious global issue. The number of diabetics in Japan has already exceeded 20 million, including those with “possibility of diabetes cannot be denied”, and the shortening of healthy life expectancy from complications and the ever-increasing medical bills have placed medical economy in a grave situation. We are conducting studies on the “elucidation of onset mechanism and treatment” for type II diabetes. Insulin hyposecretion and insulin resistance are both features of diabetes, however especially for the Japanese, insulin hyposecretion is more commonly seen and research is being conducted with the aim of “detailed elucidation of insulin secretion mechanism in pancreatic beta cells and the identification of the location of abnormality of diabetes, and the search for useful substances for treatment”

Present specialized field
General physiology, Pathological medical chemistry, Metabolomics, Endocrinology (Keyword：life style related disease, physiology, metabology, diabetes, hormone)

Papers
1.	2023/03	White-skinned sweet potato (Ipomoea batatas L.) acutely suppresses postprandial blood glucose elevation by improving insulin sensitivity in normal rats │ Heliyon │ 9 (4),pp.e14719
2.	2021/12	Development of novel radioiodinated exendin-4 derivatives targeting GLP-1 receptor for detection of β-cell mass. │ Bioorganic & Medicinal Chemistry │ 52,pp.116496
3.	2020/11	Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model. │ iScience │ 23 (12),pp.101774
4.	2020/06	Bitter melon fruit extract has a hypoglycemic effect and reduces hepatic lipid accumulation in ob/ob mice. │ Phytotherapy Research │ 34 (6),pp.1338-1346
5.	2018/01	Evaluation of 18F-labeled exendin(9-39) derivatives targeting glucagon-like peptide-1 receptor for pancreatic β-cell imaging. │ Bioorganic & Medical Chemistry │ 26 (2),pp.463-469
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Academic conference presentation
1.	2023/11	Effects of fatty acid exposure on insulin secretion and role of Nrf2 in pancreatic beta cells
2.	2023/05	White-skinned sweet potato (Ipomoea batatas L.) acutely suppresses postprandial blood glucose elevation by improving insulin sensitivity
3.	2023/03	Acute effects of branched-chain keto acids on blood glucose levels in normal rats
4.	2023/03	Role of Nrf2 in lipotoxic impairment of glucose-stimulated insulin secretion from pancreatic β-cells
5.	2019/09	Bitter melon fruit extract affects hepatic expression of the genes involved in inflammation and fatty acid metabolism in ob/ob mice
Display All（28）

Subject
1.	生命科学研究概論