研究者学術情報データベース

キタハラ　リョウ
北原　亮
KITAHARA Ryo

所属薬学部創薬科学科

職名教授

論文
1.	2024/03/01	薬学教育におけるレギュラトリーサイエンスの重要性：薬学生の食の安全に対する意識調査を通じて │ 薬学教育 │ 8,2023-36 (共著)
2.	2023/12/20	圧力軸で見る生物の極限環境適応 │ 細胞 │ 55 (12),55-59頁 (共著)
3.	2022/08/24	Phase separation by biopolymers: basics and applications │ Biophysics and Physicobiology │ 19,e190028 (共著)
4.	2022/08/04	Mechanism underlying liquid-to-solid phase transition in fused in sarcoma liquid droplets │ Phys. Chem. Chem. Phys. │ 24,19346-19353頁 (共著)
5.	2022/04/01	タンパク質がつくる液-液相分離をリアルタイムで捉えた！ -圧力ジャンプ分光法による液-液相分離研究の新展開- │ 化学 │ 77 (4),23-27頁 (単著)
6.	2022/02/25	Amplification of the Specific Conformational Fluctuation of Proteins by Site-specific Mutagenesis and Hydrostatic Pressure │ The Journal of Physical Chemistry B │ 126,1868-1875頁 (共著)
7.	2021/11/17	Pressure-Jump Kinetics of LiquidLiquid Phase Separation: Comparison of Two Different Condensed Phases of the RNA-Binding Protein, Fused in Sarcoma │ J. Am. Chem. Soc. │ 143 (47),19697-19702頁 (共著)
8.	2021/10/27	水中におけるナフタレン骨格超分子チューブと1,4-ジオキサンの複合体形成と圧力効果 │ 31 (2),90-95頁 (共著)
9.	2021/06/22	Pressure and Temperature Phase Diagram for LiquidLiquid Phase Separation of the RNA-Binding Protein Fused in Sarcoma │ Journal of Physical Chemistry B │ 125,6821-6829頁 (共著)
10.	2020/12/15	Pressure tolerance of brine shrimp (Artemia) │ High Pressure Research │ 41 (1),109-117頁 (共著)
11.	2020/10/05	Dynamic aspects of pressure and temperature-stabilized intermediates of outer surface protein A │ Proteins │ 88 (11),1423-1433頁 (共著)
12.	2020/10/01	高圧力がタンパク質に及ぼす影響〜圧力で早まるシアノバクテリアの概日時計〜 │ 化学と生物 │ 58 (10),579-584頁 (共著)
13.	2020/09/21	Volumetric Properties for the Binding of 1,4-Dioxane to Amide Naphthotubes in Water │ Journal of Physical Chemistry B │ 124,9175-9181頁 (共著)
14.	2019/10	How internal cavities destabilize a protein │ Proc. Natl. Acad. Sci. USA │ 116 (42),21031-21036 (共著)
15.	2019/10	Paramagnetic relaation enhancement-assisted structural characterization of a partially disordered conformation of ubiquitin │ Protein Science │ 28,1993-2003 (共著)
16.	2019/08	Pressure accelerates the circadian clock of cyanobacteria │ Scientific Reports │ 9,12395 (共著)
17.	2019/06	Gene delivery to cone photoreceptors by subretinal injection of rAA2/6 in the mouse retina │ Biochemical and Biophysical Research Communications │ 515,222-227 (共著)
18.	2019/06	Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53 │ Scientific Reports │ 9,8584 (共著)
19.	2019/03	Characterization of low-lying exited states of proteins by high-pressure NMR spectroscopy │ BBA Proteins and Proteomics │ 1867,350-358 (共著)
20.	2018/09	Water-protein interactions coupled with protein conformational transition │ Biophysical Journal │ 115,981-987 (共著)
21.	2018/02	Nuclear magnetic resonance-based determination of dioxygen binding sites in protein cavities │ Protein Science │ 27 (3),769-779 (共著)
22.	2017/12	NMR法で観る圧力によるタンパク質の構造変化 │ 応用糖質科学 │ 7 (4),204-209 (単著)
23.	2017/08	Interactions controlling the slow dynamic conformational motions of ubiquitin │ molecules │ 22,1414 (共著)
24.	2017/05	Analysis of O2-binding sites in proteins using gas-pressure NMR spectroscopy: Outer surface protein A │ Biophysical Journal │ 112,1820-1828 (共著)
25.	2017/04	静水圧及びガス圧NMR法を用いたタンパク質の動的性質の研究 │ 高圧力の科学と技術 │ 27 (1),13-17 (単著)
26.	2016/09	Aberrant increase of NMR signal in hydrogen exchange experiments. Observation and explanation. │ Biochemical and Biophysical Research Communications │ 478,1185-1188 (共著)
27.	2016/08	Modeling 15N NMR chemical shift changes in protein backbone with pressure │ J. Chem. Phys. │ 145,085104 (共著)
28.	2016/03	High-Pressure NMR for Studying Protein Structure and Dynamics │ 33 (1),1-26 (共著)
29.	2016/02	Detecting O2 binding sites in protein cavities. │ Scientific Reports │ 6,20534 (共著)
30.	2015/06	Zinc ion-binding activity of an anti-ZnO VHH antibody, 4F2 │ Chemistry Letters │ 44,1309-1311 (共著)
31.	2015/03	Is pressure-induced signal loss in NMR spectra for Leu99Ala cavity mutant of T4 lysozyme due to unfolding? │ Proceedings of the National Academy of Sciences, USA │ 112 (09),E923 (共著)
32.	2015/01	Cavity as a source of conformational fluctuation and high-energy state: High-pressure NMR study of a cavity-enlarged mutant of T4Lysozyme │ Biophysical Journal │ 108 (1),133-145 (共著)
33.	2014/01	Close Identity between Alternatively Folded State N2 of Ubiquitin and the Conformation of the Protein Bound to the Ubiquitin-Activating Enzyme │ Biochemistry │ 53 (3),447-449 (共著)
34.	2013/12	圧力摂動によりトラップされた蛋白質のミスフォールド状態 │ 生物物理 │ 53 (6),321-322 (共著)
35.	2013/10	Solvent Environments Significantly Affect the Enzymatic Function of Escherichia coli Dihydrofolate Reductase: Comparison of Wild-type Protein and Active-site Mutant D27E │ Biochimica et Biophysica Acta │ 1834,2782-2794 (共著)
36.	2013/05	Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43) │ J. Biol. Chem. │ 288,14886-14905 (共著)
37.	2013/04	Pressure-induced chemical shifts as probes for conformational fluctuations in proteins │ Progress in NMR spectroscopy │ 71,35-58 (共著)
38.	2013/03	Solution structure of the Q41N variant of ubiquitin as a model for the alternatively folded N2 state of ubiquitin │ Biochemistry │ 52,1874-1885 (共著)
39.	2013/02	Exploring the folding energy landscape with pressure │ Archives of Biochemistry and Biophysics │ 531,110-115 (共著)
40.	2012/10	高圧力ＮＭＲ法で観る蛋白質の高エネルギー構造 │ NMR学会機関誌 │ 3,46-49 (単著)
41.	2012/03	A delicate interplay of structure, dynamics and thermodynamics for function: A high pressure NMR and fluorescence study of Outer surface protein A │ Biophysical Journal │ 102 (4),916-926 (共著)
42.	2011/04	Structural plasticity of staphylococcal nuclease probed by perturbation with pressure and pH │ Proteins │ 79,1293-1305 (共著)
43.	2010/03	Solution structure of LC5, the CCR5-derived peptide for HIV-1 inhibition │ Journal of Peptide Science │ 16,165-170 (共著)
44.	2009/09	Pressure-dependent structure changes in barnase on ligand binding reveal intermediate rate fluctuations │ Biophysical Journal │ 97,1482-1490 (共著)
45.	2009/06	極限環境下の蛋白質の構造と機能 │ 材料 │ 58 (6),449-455 (共著)
46.	2009/03	Pressure-dependennt 13C chemical shifts in proteins: origins and applications │ Journal of Biological NMR │ 44 (1),25-33 (共著)
47.	2009/01	可変圧力ＮＭＲ法によるユビキチン様蛋白質に保存された構造揺らぎの発見 │ 生物物理 │ 49 (1),20-22 (単著)
48.	2008/02	可変圧力ＮＭＲ法による蛋白質の準安定構造解析 │ 高圧バイオサイエンスとバイオテクノロジー │ 2,8-14 (共著)
49.	2008/02	蛋白質の準安定構造 │ 生物物理 │ 48,41-45 (単著)
50.	2008/01	Basic folded and low-populated locally-disordered conformers of SUMO-2 characterized by NMR spectroscopy at varying pressure │ Biochemistry │ 47,30-39 (共著)
51.	2007/08	Local conformational transition of Hydrogenobacter thermophilus cytochrome c552 relevant to its redox potential │ Biochemistry │ 46,9215-9224 (共著)
52.	2007/02	揺らぐ蛋白質構造の解析―可変圧力NMRからのアプローチ │ 高圧力の科学と技術 │ 17 (1),32-41 (共著)
53.	2006/10	Evolutionally　conserved intermediates between ubiquitin and NEDD8 │ Journal of Molecular Biology │ 363,395-404 (共著)
54.	2006/07	Cold denaturation of ubiquitin at high pressure │ Magnetic Resonance in Chemistry │ 44,s108-s113 (共著)
55.	2006/01	可変圧力ＮＭＲ法による新しい蛋白質構造パラダイムの構築 │ 分光研究 │ 55 (1),10-20 (共著)
56.	2005/03	NMR snapshots of a fluctuating protein structure. Ubiqutin at 30 bar-3 kbar │ Journal of　Molecular Biology │ 347,277-285 (共著)
57.	2004/09	High pressure NMR spectroscopy for characterizing non-native conformers of proteins │ Methods │ 34,133-143 (共著)
58.	2004/06	High pressure NMR study of dihydrofolate reductase from a deep-sea bacterium Moritella profunda │ Cellar Molecular Biology │ 50,311-316 (共著)
59.	2003/03	Close identity of a pressure stabilized intermediate with a kinetic intermediate in protein folding │ Proceeding of National Academic Science USA │ 100,3167-3172 (共著)
60.	2003/02	High-pressure 1H NMR study of pressure -induced structural changes in the heme environments of metcyanomyoglobin │ Protein Science │ 12,207-217 (共著)
61.	2002/07	Equilibrium and pressure-jump relaxation studies of the conformational transitions of P13MTCP1 │ Journal of. Molecular. Biology │ 320,609-628 (共著)
62.	2002/07	High pressure NMR reveals that apomyoglobin is an equilibrium mixture from the native to the unfolded │ Journal of. Molecular. Biology │ 320,311-319 (共著)
63.	2001/11	Two folded conformers of ubiquitin revealed by high pressure NMR │ Biochemistry │ 40,13556-13563 (共著)
64.	2000/10	High Pressure NMR reveals active-site hinge motion of folate-bound Escherichia coli dihydrofolate reductase │ Biochemistry │ 39,12789-12795 (共著)