Researcher Database

（Last updated : 2022-02-01 21:47:16）

ITO Masahiro

Department / Course College of Life Sciences Department of Bioinformatics

Title / Position Professor

Other Affiliations
1.	Graduate School of Life Sciences

Academic background
1.		│ "Japan Advanced Institute of Science and Technology\, Hokuriku" Ph.D. (Computer and Information Sciences)

Business career
1.	2008/04 ～ 2013/03	Associate Professor │ │
2.	1994/10 ～ 1996/09	│ │ Protein Engineering Research Institute

Research activities
1.		Japanese Society for Bioinformatics
2.		The Molecular Biology Society of Japan

Research summary
Research on understanding biological systems based on genomes With the completion of the decoding of the human genome and various other genome sequences, the central paradigm of biology has become that "biological information goes from DNA to RNA to protein, and eventually forms cells and individuals. However, in addition to proteins, two other types of molecules, lipids and carbohydrates, are essential for the formation of cells. Lipids and carbohydrates are deeply involved in signaling molecules, metabolism, the construction of biological structures, and biological diversity, as well as the precursors of bioenergy. Therefore, in order to understand the individual organism, it is necessary to extend the central paradigm to include lipids, carbohydrates, and complex carbohydrates (glycolipids, glycoproteins, etc.) and to understand them in an integrated manner. 　The ultimate goal of our laboratory is to "reconstruct (recreate) the program of biological activity", and our current research is focused on the following four themes: "understanding of the biogenesis system", "understanding of the synthetic pathways and functions of glycolipids", "identification of lipid mediators and understanding of their physiological functions", and "understanding of the robustness of metabolic reaction networks". Our research is focused on the following four themes.

Present specialized field
Genome biology, System genome science, Evolutionary biology, Structural biochemistry (Keyword：Information Biology, Bioinformatics, Genome Biology)

Books
1.	2021/03/23	Coronavirus Disease (COVID-19): Nima Rezaei Retrieval and Investigation of Data on SARS-CoV-2 and COVID-19 Using Bioinformatics Approach │ (Co-authored)

Papers
1.	2022/04/27	The PAF1 complex cell autonomously promotes oogenesis in Caenorhabditis elegans. │ Genes to cells │ 27 (6),pp.409-420 (Co-authored)
2.	2022/01	In silico analysis of SARS-CoV-2 ORF8-binding proteins reveals the involvement of ORF8 in acquired-immune and innate-immune systems │ Frontiers in Medicine │ Accepted (Co-authored)
3.	2021/11/29	A class I histone deacetylase HDA-2 is essential for embryonic development and size regulation of fertilized eggs in Caenorhabditis elegans │ Genes and Genomics │ (Co-authored)
4.	2021	Zinc finger protein 483 (ZNF483) regulates neuronal differentiation and methyl-CpG-binding protein 2 (MeCP2) intracellular localization. │ Biochem Biophys Res Commun │ 568,pp.68-75 (Co-authored)
5.	2021	Overlapping and Non-Overlapping Roles of the Class-I Histone Deacetylase-1 Corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans Embryonic Development │ Genes and Genomics │ (Co-authored)
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Academic conference presentation
1.	2020/12/04	Phylogenetic profiling illuminates the functional classification of ORF8 in SARS-CoV-2 (第43回日本分子生物学会年会)
2.	2019/12/06	Rett Syndrome-causing proteins and their pathogenic missense point mutations: structural order disorder,post-translational modifications,and evolutionary rates (第42回日本分子生物学会年会)
3.	2019/08/21	Evolutionary and functional assessment of Rett syndrome-related proteins
4.	2019/08/21	Functional analysis of PAF1 complex using Caenorhabditis elegans
5.	2019/07/23	Phylogenetic profile analysis of Rett syndrome-related proteins (27th Intelligent Systems for Molecular Biology (ISMB/ECCB))
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External Researcher ID
ORCID ID
0000-0001-8364-8440
Researcher ID
read0210434