Researcher Database

（Last updated : 2024-03-01 14:51:14）

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NISHIZAWA Mikio

Department / Course College of Life Sciences Department of Biomedical Sciences

Title / Position Professor

Other Affiliations
1.	Graduate School of Life Sciences
2.	Ritsumeikan Asia-Japan Research Organization Asia-Japan Research Institute

Academic background
1.	1987/09 Degree Acquisition	│ Tohoku University Ph.D. (Doctor of Medicine)
2.	～1987/03	Doctorial Course │ School of Medicine, Graduate Course │ Tohoku University │ Completed Medical biochemistry Ph.D.
3.	1983/05 Degree Acquisition	│ Ministry of Health, Labour and Welfare, Japan The Physician's License from the Ministry of Health, Labour and Welfare, Japan
4.	～1983/03	Department of Medicine │ School of Medicine │ Toyama Medical and Pharmaceutical University │ Graduated

Business career
1.	2008/04/01	Professor │ Institute of Science and Engineering, College of Life Sciences, │
2.	2007/04/01 ～ 2008/03/31	Professor │ Department of Bioscience and Biotechnology, College of Science and Engineering, │
3.	1997/04/01 ～ 2007/03/31	Lecturer │ the Department of Medical Chemistry │ Kansai Medical University
4.	1995/05/01 ～ 1997/03/31	Assistant researcher │ the Department of Medical Chemistry │ Kansai Medical University
5.	1993/06/01 ～ 1995/04/30	Post-doctoral fellow │ Department de Biologie Moleculaire et Biochimie, Faculte des Sciences, │
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Research activities
1.		The Japanese Biochemical Society
2.		The Japanese Biochemical Society, Kinki Branch
3.		The Molecular Biology Society of Japan
4.		The Japanese Cancer Association
5.		The Japanese Society for Research of Hepatic Cells
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Subject of research
1.	(1)Regulation mechanism of cytokine gene expression by natural antisense transcripts and application to development of novel drugs

Research summary
Regulation mechanism of cytokine gene expression by natural antisense transcripts and application to development of novel drugs Central dogma, namely, DNA makes RNA makes protein, indicates that information encoded in DNA (blueprint of life) is transmitted to messenger RNA (mRNA) and then translated to protein that works in the cell. Recently it is reported that there are number of RNA that is not translated to protein in mammalian cells. The untranslated RNA (non-coding RNA) was thought to have no useful functions. We have found antisense transcripts (antisense RNA), one type of non-coding RNAs, and elucidated that the antisense RNA stabilizes mRNA and regulates gene expression. The antisense RNA is transcribed from a gene encoding inducible nitric oxide synthase (iNOS). This enzyme catalyzed the reaction to produce nitric oxide (NO), which kills viruses and bacteria during infection, while excess NO may cause tissue damage or septic shock. We attempt to degrade mRNA by inhibiting stabilizing activity of the antisense RNA finally to reduce excess NO production. Collaborators: Ritsumeikan University: Tominori Kimura, Tadayoshi Okumura; Yukinobu Ikeya (Daiichi University of Pharmacy), Masaki Kaibori (Kansai Medical University), Koji Wakame (Hokkaido Pharmaceutical University School of Pharmacy), Kenji Sato (Kyoto University).

Present specialized field
Pathological Medical Chemistry, Medical biochemistry, Pharmacology (Keyword：Natural antisense transcript, cytokine, chemokine, nitric oxide, inducible nitric oxide synthase, gene, gene regulation, hepatocytes, inflammation, drug)

Books
1.	2022/10/19	The Natural Antisense Transcript-Targeted Regulation Technology Using Sense Oligonucleotides and Its Application │ ,pp.1-19 (Co-authored)
2.	2016/10	Clinician's Guide to AHCC: Evidence-Based Nutritional Immunotherapy │ ,pp.109-115,134-143 (Co-authored)

Papers
1.	2023/08/16	Hydrophobic constituents of Polygonum multiflorum roots promote renal erythropoietin expression in healthy mice │ Journal of Natural Medicines │ 77,pp.880-890 (Co-authored)
2.	2023/07/01	Combination therapy with a sense oligonucleotide to inducible nitric oxide synthase mRNA and human soluble thrombomodulin improves survival of sepsis model rats after partial hepatectomy │ Shock │ 60 (1),pp.84-91 (Co-authored)
3.	2023/06/28	Identification of Anti-Inflammatory Compounds from Peucedanum praeruptorum Roots by Using Nitric Oxide-Producing Rat Hepatocytes Stimulated by Interleukin 1β │ Molecules │ 28 (5076) (Co-authored)
4.	2023/04	White-skinned sweet potato (Ipomoea batatas L.) acutely suppresses postprandial blood glucose elevation by improving insulin sensitivity in normal rats │ Heliyon │ 9 (4),pp.e14719 (Co-authored)
5.	2022/08	Anti-inflammatory effects of hydrophobic constituents in the extract of the root cortex of Paeonia suffruticosa │ Bioactive Compounds in Health and Disease │ 5 (8),pp.160-173 (Co-authored)
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Academic conference presentation
1.	2023/09/13	Research on Traditional Medicine in Japan and Indonesia (Dewan Jamu (Jamu Conference))
2.	2023/09/11	Research on Traditional Medicine and Functional Foods (Special Seminar on Food Analysis "Prospective Foods for Well-being in Indonesia and Japan" in Partnership with IPB University 2023)
3.	2023/07/09	Identification of anti-inflammatory constituents from Alpinia zerumbet (The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicines (ICNIM2023))
4.	2023/07/08	Constituents in green perilla and red perilla suppress production of nitric oxide (The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicines (ICNIM2023))
5.	2023/07/08	Effects of AHCC® on hepatic ischemia-reperfusion injury and partial hepatectomy in rats (The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicines (ICNIM2023))
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Works
1.	2023/07/26	Evaluation of Traditional Japanese Medicine and Functional Foods (IPB, Bogor)
2.	2022/07/13	Traditional Japanese Medicine and Functional Foods (IPB（オンライン開催）)
3.	2022/04/06	Traditional Japanese Medicine and Crude Drugs (Vietnam National University of Agriculture)

Winning science prize
1.	1992/01	Alexander von Humboldt Foundation Alexander von Humboldt-Forschungsstipendium (1992)-

Grants-in-Aid for Scientific Research -KAKENHI-
1.	2015/04 ～ 2018/03	Development of next-generation nucleic acid medicines based on the anti-influenza viral regulatory antisense RNA │ Grant-in-Aid for Scientific Research (C)

Acquisition patent
1.	2014/03	COMPOUND, MEDICINE, ANTI-INFLAMMATORY, COSMETIC, FOOD AND DRINK, AND METHOD FOR PRODUCING COMPOUND （特願2013-181052）

Research exchange preferred theme
1.	Study on regulation mechanism of gene expression and application to design of drugs Study on regulation mechanism of gene expression (focused on the genes induced during inflammation, such as iNOS gene) and application to design of drugs (including anti-inflammatory drugs) Commisioned research Joint research

External Researcher ID
ORCID ID
0000-0002-1117-2807