Researcher Database

（Last updated : 2025-04-07 14:10:57）　

MIHARA Hisaaki

Department / Course College of Life Sciences Department of Biotechnology

Title / Position Professor

Click to view the Scopus page. The data was downloaded from Scopus API on Apr 14, 2025. via http://api.elsevier.com and http://www.scopus.com .

Other Affiliations
1.	Graduate School of Life Sciences
2.	Research Organization of Science and Technology Earth & Space Exploration Center

Academic background
1.	1999/09 Degree Acquisition	│ Kyoto University Ph.D. (Agriculture) (Applied microbiology)
2.	1995/04～1999/03	Doctoral Program (2nd Semester) │ Agricultural Chemistry Major │ Graduate School, Division of Agriculture │ Kyoto University │ Accomplished credits for doctoral program
3.	1993/04～1995/03	Master Course │ Agricultural Chemistry Major │ Graduate School, Division of Agriculture │ Kyoto University │ Completed
4.	1989/04～1993/03	Department of Agricultural Chemistry │ Faculty of Agriculture │ Kyoto Prefectural University │ Graduated

Business career
1.	2024/04 ～	Fellow │ │ Ritsumeikan Advanced Research Academy (RARA)
2.	2014/04/01 ～	Professor │ College of Life Sciences │ Ritsumeikan University
3.	2009/04 ～ 2014/03	Associate Professor │ College of Life Sciences, │ Ritsumeikan University

Research activities
1.		The Japanese Biochemical Society
2.		Japan Society for Bioscience, Biotechnology, and Agrochemistry
3.		THE VITAMIN SOCIETY OF JAPAN
4.		Japan Society for Biomedica1 Research on Trace Elements
5.		Japan Trace Nutrients Research Society

Subject of research
1.	Production of useful chiral compounds with microbial enzymes
2.	Structure and function of enzymes involved in trace element/metal metabolism

Research summary
Analysis of structural functions of microorganisms and enzyme that are involved in the metabolism of metals and microelements, and application to the environmental cleanup, resource recovery and useful substance production I analyze microelements, particularly enzymes that are involved in the metabolism of selenium and aim to apply their functions to the environmental cleanup and substance production. In addition, I establish a new production system of chiral compound useful for the industry using microbial enzymes.

Present specialized field
Bio-related chemistry, Biofunction/Bioprocess, Structural Biochemistry, Functional Biochemistry, Applied Microbiology, Applied Biochemistry, Biological Production Chemistry/Biological Organic Chemistry (Keyword：enzyme, trace element, selenium, sulfur, selenoprotein, metal, microbe, chiral compound, bacteria, protein, cofactor, coenzyme, vitamin)

Books
1.	2017	Selenium in Plants │ ,pp.79-108
2.	2016/09	Selenium: Its Molecular Biology and Role in Human and Health 4th Ed. │ ,pp.113-123
3.	2014/01	Selenium in the Environment and Human Health │ ,pp.181
4.	2012/01	Selenium: Its Molecular Biology and Role in Human and Health │ ,pp.95-105
5.	2010/01	Practical Methods for Biocatalysis and Biotransformations │ ,pp.310-313

Papers
1.	2025/01	Structural insights into the mechanism underlying the dual cofactor specificity of glyoxylate reductase from Acetobacter aceti in the β-hydroxyacid dehydrogenase family. │ Biochimica et biophysica acta. Proteins and proteomics │ 1873 (1),pp.141051
2.	2024/08	Comparative studies on substrate specificity of succinic semialdehyde reductase from Gluconobacter oxydans and glyoxylate reductase from Acetobacter aceti. │ Bioscience, biotechnology, and biochemistry │ 88 (9),pp.1069-1072
3.	2024/04/03	Effects of genetic disruption in thioredoxin and glutathione systems on selenium nanoparticle formation, selenite sensitivity, and selenoprotein biosynthesis in Escherichia coli │ Metallomics Research │ 4 (1),pp.reg14-reg20
4.	2024/03/20	Selenium Nanoparticles Synthesized and Stabilized by Fungal Extract Exhibit Enhanced Bioactivity │ Journal of Cluster Science │ 35 (5),pp.1425-1437
5.	2023/01/17	Comparison of Nutritional Availability of Biogenic Selenium Nanoparticles and Chemically Synthesized Selenium Nanoparticles │ Biological Trace Element Research │ 201 (10),pp.4861-4869
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Academic conference presentation
1.	2019/12/23	Selenium metabolism in bacteria
2.	2019/12/23	The NsrR is essential for the function of selenate/tellurate reductase via activation of the moeA gene in Escherichia coli
3.	2019/11/22	Role of outer membrane porin ExtI in selenite reduction in a metal-reducing bacterium
4.	2019/11/21	Function and structure of multiheme-containing selenoprotein
5.	2019/09/21	Substrate specificity of DlcA of D-lysine ABC transporter from Psuedomonas putida
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