Researcher Database

（Last updated : 2024-06-05 12:40:25）

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KANEKO-KAWANO Takako

Department / Course College of Pharmaceutical Sciences Department of Pharmacy

Title / Position Associate Professor

Other Affiliations
1.	Graduate School of Pharmacy

Academic background
1.		Doctoral Program (1st Semester) │ Division of Cellular Biology │ Graduate School of Biological Sciences │ Nara Institute of Science and Technology │ Completed (Cell biology)
2.		Doctoral Program (2nd Semester) │ Division of Cellular Biology │ Graduate School of Biological Sciences │ Nara Institute of Science and Technology │ Completed (Cell biology)
3.		Faculty of Pharmaceutical Science │ Kyoto Pharmaceutical University │ Graduated

Business career
1.	2015/04	Associate Professor │ College of Pharmaceutical Science, │ Ritsumeikan University
2.	2010/04 ～ 2015/03	Assistant Professor │ College of Pharmaceutical Science, │ Ritsumeikan University
3.	2009/08 ～ 2010/03	Assistant Professor │ Office for Gender Equality, │ Nagoya University
4.	2009/04 ～ 2009/07	Postdoctoral Fellow │ Department of Information andComputer Sciences, │ Nara Women’s University
5.	2006/05 ～ 2009/03	Postdoctoral Fellow │ Department of Systems Biology, Graduate School of Information Science, │ Nara Institute of Science and Technology
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Research activities
1.		The American Society for Cell Biology
2.		The Pharmaceutical Society of Japan
3.		The Molecular Biology Society of Japan
4.		Japan Society for Cell Biology
5.		The Japanese Society for Mathematical Biology
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Qualification and license
1.		License to practice Pharmacy

Subject of research
1.	Analysis of dynamic regulation of cell migration
2.	Analysis of dynamic regulation of endothelial permeability

Research summary
Control principle of cellular functions It is essential for inducing normal cellular functions to control the spatiotemporal activities of signaling molecules appropriately. However, it has not been clarified what mechanisms regulates harmonic patterns and rhythms of signaling molecules activities. My goal is to elucidate the control principle producing the harmonic patterns and rhythms of signaling molecules activities in the cells. In mathematical biology, it has been reported that some theories can explain to produce spontaneous patterns and rhythms. Therefore, I have clarified the control principles producing patterns and rhythms using both theoretical and experimental analyses.

Present specialized field
Cell Biology, Systems Biology, General medical chemistry, Pathological Medical Chemistry, Biological pharmacy, Environmental and hygienic pharmacy (Keyword：systems biology, computer simulation, smooth muscle, cell migration)

Papers
1.	2024/05/30	An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function. │ Nat Commun. │ 15 (1),pp.4610 (Co-authored)
2.	2024	Molecular Mechanisms Regulating Vascular Endothelial Permeability │ Int. J. Mol. Sci. │ (Co-authored)
3.	2021/11	The small GTPase OsRac1 forms two distinct immune receptor complexes containing the PRR OsCERK1 and the NLR Pit. │ Plant Cell Physiol. │ 62 (11),pp.1662-1675 (Co-authored)
4.	2020/02	Identification of endogenous small peptides involved in rice immunity through transcriptomics- and proteomics-based screening │ Plant Biotechnol J. │ 18 (2),pp.415-428 (Co-authored)
5.	2019/11	In silico study of Rett syndrome treatment-related genes, MECP2, CDKL5, and FOXG1, by evolutionary classification and disordered region assessment │ Int. J. Mol. Sci. │ 20 (22),pp.E5593 (Co-authored)
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Academic conference presentation
1.	2023/03/27	Autodephosphorylation of myosin phosphatase regulates cell migration
2.	2022/03/28	Autodephosphorylation of Myosin Phosphatase Regulates Endothelial Permeability
3.	2020/06/15	Auto-dephosphorylation of myosin phosphatase regulates endothelial permeability (The 72nd Annual Meeting of the Japan Society for Cell Biology)
4.	2019/12	Auto-dephosphorylation of myosin phosphatase regulates vascular endothelial barrier function (ASCB/EMBO 2019 meeting)
5.	2019/12	Auto-dephosphorylation of myosin phosphatase regulates vascular endothelial barrier function
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Winning science prize
1.	2013/04	Inamori Foundation Seiwa Scholarship

E-Mail Address