Researcher Database

（Last updated : 2024-04-19 20:00:58）

KATSURA TOSHIYA

Department / Course College of Pharmaceutical Sciences Department of Pharmacy

Title / Position Professor

Other Affiliations
1.	Graduate School of Pharmacy

Academic background
1.	1993/03 Degree Acquisition	│ Kyoto University Ph.D.
2.	～1988/03	Division of Pharmaceutical Chemistry │ Faculty of Pharmaceutical Sciences │ Kyoto University │ Graduated
3.	～1993/03	Doctoral Program (2nd Semester) │ Division of Pharmacy │ Graduate School of Pharmaceutical Sciences │ Kyoto University │ Completed

Business career
1.	2013/04/01	Professor │ College of Pharmaceutical Sciences │ Ritsumeikan University
2.	2007/04/01 ～ 2013/03/31	Associate Professor and Vice Director │ Departmentof Pharmacy │ Kyoto University Hospital
3.	2004/12/01 ～ 2007/03/31	Associate Professor and Vice Director │ Departmentof Pharmacy │ Kyoto University Hospital
4.	2003/01/01 ～ 2004/11/30	Lecturer │ Department of Pharmacy │ Kyoto University Hospital
5.	1996/09/01 ～ 2002/12/31	Assistant Professor │ Department of Pharmacy │ Kyoto University Hospital
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Committee and society
1.	2014/03 ～ 2016/03	Journal of Pharmaceutical Health Care and Sciences Editor-in-Chief
2.	2013/07 ～	Journal of Pharmaceutical Sciences Scientific Advisor to the Editors

Research activities
1.		American Association of Pharmaceutical Scientists
2.		Japanese Society of Pharmaceutical Health Care and Sciences
3.		Japanese Society of Nephrology
4.		The Pharmaceutical Society of Japan
5.		The Academy of Pharmaceutical Science and Technology, Japan
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Subject of research
1.	Molecular/Cellular Biological Research on Drug Transporter
2.	Study on Function/Expression Changes of Drug Transporter
3.	Study on Tissue Distribution and Side-effect Expression of Drugs

Research summary
Elucidation of drug pharmacokinetics variation factors and individualized administration design and the study on proper use of pharmaceuticals Pharmacokinetics of drugs are closely linked to the effectiveness and safety of pharmaceuticals. In our laboratory, study is being pursued focused on drug transporters, one of the regulating factors of drug pharmacokinetics. In other words, the correlation analysis of drug transporter function and onset variation and drug pharmacokinetic variation and the elucidation of drug interaction mechanism through drug transporters, tissue build-up of drugs through drug transporters and the relation with the onset of side effect etc., are being conducted from molecular level to individual level, using diverse experimental systems to conduct systematic analysis, aiming to contribute to the proper use of pharmaceuticals by solving the issues in pharmacotherapy.

Present specialized field
Medical pharmacy, Applied pharmacology, Pharmacology in pharmacy, Biological pharmacy (Keyword：Drug Transporter, Pharmacokinetics, Appropriate Use of Drugs, Drug Interaction, Personalized Medicine, Polarized Epithelial Cells)

Papers
1.	2024	Association of direct oral anticoagulant and delayed bleeding with pharmacokinetics after endoscopic submucosal dissection. │ Gastrointestinal Endoscopy │ in press (Co-authored)
2.	2024	Pharmacokinetic properties of CYP3A substrate midazolam associated with xenobiotic-mediated CYP induction in inflammation model mice │ BPB Reports │ in press (Co-authored)
3.	2023/10	Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models. │ Biopharmaceutics & Drug Disposition │ 44 (5),pp.351-357 (Co-authored)
4.	2022/09	Decreased serum copper concentrations by zinc administration in preterm infants with hypozincemia are associated with a lower postmenstrual age: A single-center retrospective observational study. │ YAKUGAKU ZASSHI │ 142 (9),pp.999-1004 (Co-authored)
5.	2022/07	Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis. │ Xenobiotica │ 52 (7),pp.758-766 (Co-authored)
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Academic conference presentation
1.	2023/09/28	Pharmacogenomic analysis of risk factors for bleeding events in Japanese patients with atrial fibrillation treated with apixaban (2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics in Shizuoka)
2.	2019/12/10	Quantitative evaluation of the contribution of CYP3A4 and CYP3A5 to amiodarone pharmacokinetics in human from in vitro data (The 34th Annual Meeting of the Japanese Society for the Study of Xenobiotics)
3.	2018/10/04	Association of genetic polymorphisms in drug transporters and enzymes with plasma concentrations of rivaroxaban in Japanese patients with atrial fibrillation (2018 International Meeting on 22nd Microsomes and Drug Oxidations and 33rd Japanese Society for the Study of Xenobiotics)
4.	2018/07/02	Population pharmacokinetics and pharmacodynamics of apixaban in Japanese patients with atrial fibrillation (18th World Congress of Basic and Clinical Pharmacology)
5.	2017/11/13	Population pharmacokinetics and pharmacogenomics of apixaban in Japanese patients. (2017 AAPS Annual Meeting and Exposition)
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Winning science prize
1.	2013/10	The Japanese Society for the Study of Xenobiotics DMPK Editors' Award for the Most Excellent Article in 2012 (Impact of genetic variation in breast cancer resistance protein (BCRP/ABCG2) on sunitinib pharmacokinetics.)
2.	2007/10	The Japanese Society for the Study of Xenobiotics DMPK Award for the Most Frequently Cited Review Article in 2003 (Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation)
3.	2006/11	The Japanese Society for the Study of Xenobiotics DMPK Award for the Most Frequently Downloaded Review Article in 2003 (Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation.)