Researcher Database

（Last updated : 2025-02-28 15:11:44）　

HIKIRI SIMON

Department / Course College of Life Sciences Department of Bioinformatics

Title / Position Assistant Professor

Papers
1.	2022/10	A methodology for creating mutants of G‐protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering │ Protein Science │ 31 (10),pp.e4425
2.	2020/08	Comparison based on statistical thermodynamics between globule-to-coil transition of poly(N-isopropylacrylamide) and cold denaturation of a protein │ Journal of Molecular Liquids │ 317 (1),pp.114129
3.	2020/02	Hydration properties of a protein at low and high pressures: Physics of pressure denaturation │ Journal of Chemical Physics │ 152 (6),pp.065103
4.	2019/10	Mechanism of globule-to-coil transition of poly(N-isopropylacrylamide) in water: Relevance to cold denaturation of a protein │ Journal of Molecular Liquids │ 292 (15),pp.111374
5.	2019/08	How Does the Recently Discovered Peptide MIP Exhibit Much Higher Binding Affinity than an Anticancer Protein p53 for an Oncoprotein MDM2? │ Journal of Chemical Information and Modeling │ 59 (8),pp.3533
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Papers

2022/10

2020/08

2020/02

2019/10

2019/08

Academic conference presentation
1.	2024/06/25	Development of drug discovery platform technology based on a generalized-ensemble simulation method -Evaluation of SARS CoV-2 PLpro candidate inhibitors-
2.	2024/06/25	Investigations of hydration structures and dynamics around proteins and peptides with MD simulations
3.	2024/06/25	The effect of the 2-OH group of ceramide in Arabidopsis thaliana on plant cell membranes using MD simulation
4.	2024/06/25	Verification of the effect of ligand and receptor flexibility on inhibitory activity by MD simulation

Academic conference presentation

2024/06/25

2024/06/25

2024/06/25

2024/06/25