オガワ ケイコ
小川 慶子
OGAWA Keiko
所属 薬学部 薬学科
職名 助教
言語種別 日本語
発行・発表の年月 2018/03
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1.
執筆形態 共著
掲載誌名 Journal of natural medicines
掲載区分 国外
巻・号・頁 72(2),439-447
担当区分 筆頭著者
著者・共著者 Ogawa Keiko, Nakamura Seikou, Hosokawa Kohei, Ishimaru Hanako, Saito Natsuki, Ryu Kaori, Fujimuro Masahiro, Nakashima Souichi, Matsuda Hisashi
概要 Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V-VIII were isolated. The structural determination of new compounds damasterpenes V-VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.
DOI 10.1007/s11418-017-1166-6
ISSNコード 1861-0293
PMID 29288328