オガワ ケイコ
小川 慶子
OGAWA Keiko
所属 薬学部 薬学科
職名 助教
言語種別 日本語
発行・発表の年月 2016/08
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 Structure of a Coumaric Acid Analogue with a Monoterpene Moiety from the Flowers of Osmanthus fragrans var. aurantiacus and Evaluation of Cinnamic Acid Analogues as Nitric Oxide Production and Degranulation Inhibitors.
執筆形態 共著
掲載誌名 Natural product communications
掲載区分 国外
巻・号・頁 11(8),1123-1128
著者・共著者 Nakamura Seikou, Liu Jiang, Nakashima Souichi, Ogawa Keiko, Ueda Takashi, Onishi Eri, Kurooka Kiwako, Moriwaki Yuko, Ryu Kaori, Xu Bin, Matsumoto Takahiro, Ohta Tomoe, Fukaya Masashi, Yoshikawa Masayuki, Matsuda Hisashi
概要 A coumaric acid analogue with a monoterpene moiety named floraosmanol A (1) was isolated from the flowers of Osmanthis fragrans var. aurantiacus. The chemical structure was elucidated on the basis of chemical and physicochemical evidence. Floraosmanol A (1) significantly inhibited nitric oxide .(NO) production in lipopolysaccharide- (LPS) activated RAW264.7 macrophages and the release of P-hexosaminidase as a marker of degranulation from rat basophile leukemia (RBL-2H3) cells. In addition, several cinnamic acid analogues were conjugated with geraniol and 3-methyl-2-buten-1-ol through an ester linkage. The inhibitory effects on NO production and the release of P-hexosaminidase of the synthesized compounds were examined for structure-activity relationships.
ISSNコード 1934-578X
PMID 30725574