オガワ ケイコ
小川 慶子
OGAWA Keiko
所属 薬学部 薬学科
職名 助教
言語種別 日本語
発行・発表の年月 2017/05
形態種別 研究論文(学術雑誌)
標題 Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity.
執筆形態 共著
掲載誌名 Phytochemistry
掲載区分 国外
巻・号・頁 137,101-108
著者・共著者 Matsumoto Takahiro, Nakamura Seikou, Nakashima Souichi, Ohta Tomoe, Ogawa Keiko, Fukaya Masashi, Tsukioka Junko, Hasei Tomohiro, Watanabe Tetsushi, Matsuda Hisashi
概要 Six neolignan glucosides, named isodonosides I-VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolignan and megastigmane glucosides were determined by derivatizations, by ECD (electronic circular dicroism) Cotton effect approximation, and by the modified Mosher's method. In addition, a significant cell protective effects of neolignan glucosides on benzo[a]pyrene-induced cytotoxicity was found.
DOI 10.1016/j.phytochem.2017.02.007
ISSNコード 1873-3700
PMID 28209279