オガワ ケイコ
小川 慶子
OGAWA Keiko
所属 薬学部 薬学科
職名 助教
言語種別 日本語
発行・発表の年月 2017/10/25
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 Oxazonigelladine and dolabellane-type diterpene constituents from Nigella damascena seeds
執筆形態 共著
掲載誌名 Tetrahedron
掲載区分 国外
巻・号・頁 73(50),7054-7060
総ページ数
担当区分 筆頭著者
著者・共著者 KeikoOgawaSeikouNakamuraYumikoAsadaMasayukiYamashitaHisashiMatsuda
概要 An alkaloid with a novel skeleton, oxazonigelladine (1), and four new dolabellane-type diterpenes, damasterpenes I (2) – IV (5), were isolated from the seeds of Nigella damascena. Oxazonigelladine has an isoxazolidinone partial structure bearing a direct bond between a nitrogen atom and an oxygen atom. This small and simple structure is quite rare in the nature. Surprisingly, despite the unstable bond between nitrogen and oxygen, oxazonigelladine was isolated with good stability. On the other hand, damasterpenes are dolabellane-type diterpenes with phenylacetyl, benzoyl, acetyl or nicotinoyl moieties. This report deals with the structure determination including the absolute configuration by X-ray crystallographic analysis and CD analysis.