アブドアルカーディル ルディ
ABDALKADER RODI
ABDALKADER RODI
所属 立命館グローバル・イノベーション研究機構
職名 助教
言語種別 日本語
発行・発表の年月 2019/12
形態種別 研究論文(学術雑誌)
査読 査読あり
標題 Evaluation of the Theranostic Potential of Perfluorohexane-Based Acoustic Nanodroplets.
執筆形態 共著
掲載誌名 Biological & pharmaceutical bulletin
掲載区分 国内
巻・号・頁 42(12),2038-2044
担当区分 筆頭著者
著者・共著者 Abdalkader Rodi, Unga Johan, Yamashita Fumiyoshi, Maruyama Kazuo, Hashida Mitsuru
概要 In this study, we have prepared perfluorohexane (PFH)-based acoustic nanodroplets (PFH-NDs) and evaluated their theranostic characteristics. Nile Red (NR) was incorporated into PFH-NDs as a model of hydrophobic drugs (NR-PFH-NDs). The mean particle diameters of PFH-NDs and NR-PFH-NDs were 205 ± 1.8 nm and 346.3 ± 6 nm, respectively. There was no significant PFH leakage from PFH-NDs during 90 min incubation at 37°C in the presence of 10% rat serum. The in vitro ultrasonography showed that the phase transition of PFH-NDs from liquid droplets to gassed bubbles could be induced by therapeutic low-intensity ultrasound with a frequency of 1 MHz and an intensity of 5 W/cm2. Irradiation of ultrasound in combination with NR-PFH-NDs enhanced uptake of NR in murine adenocarcinoma cells (C26). After intravenous injection of PFH-NDs to mice, PFH gradually disappeared from blood circulation with an elimination half-life of 43.3 min. Intravenous injection of PFH-NDs also resulted in significant contrast enhancement in the mouse carotid artery upon therapeutic low-intensity ultrasound irradiation. These results suggest the potential of PFH-NDs as a novel contrast agent for further theranostic applications.
DOI 10.1248/bpb.b19-00525
ISSNコード 1347-5215
PMID 31554747