研究者学術情報データベース

コイケ　チエコ
小池　千恵子
KOIKE Chieko

所属薬学部創薬科学科

職名教授

論文
1.	2025/12/22	Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions │ eLife │
2.	2025/11	A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness │ Journal of General Physiology │
3.	2025/08	Hidden Markov models reveal behavioral state dynamics in depth-related locomotion in mice │ PLOS One │ 20 (8)
4.	2025/07	Hidden Markov Model-Based Behavioral Classification Reveals Visual Function Recovery After Retinal Organoid Transplantation in Mice │ J Neurosci Res │ 103 (7),e70068
5.	2025/07/08	Graft-derived horizontal cells contribute to host-graft synapses in degenerated retinas after retinal organoid transplantation. │ Stem Cell Reports. │ 20 (7)
6.	2025/01/03	Transplantation of genome edited retinal organoids restores light-adapted retinal function in the retina of advanced retinal degeneration │ Stem Cell Report │ 2024 (102393)
7.	2023/12/20	圧力軸で見る生物の極限環境適応 │ 細胞 │ 55 (14),1153-1157頁
8.	2023/03/17	Effects of Astaxanthin, Lutein, and Zeaxanthin on Eye-Hand Coordination and Smooth-Pursuit Eye Movement after Visual Display Terminal Operation in Healthy Subjects: A Randomized, Double-Blind Placebo-Controlled Intergroup Trial │ Nutrients │ 15 (6),1459
9.	2022/11/14	Mathematical analysis of phototransduction reaction parameters in rods and cones │ Scientific Reports │ 12 (1),19529
10.	2022/05/17	Ablation of Ctrp9, ligand of adipoR1, and lower number of cone photoreceptors in mouse retina │ IOVS │ 63 (5),14
11.	2021/03/30	Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior. │ Molecular Brain │ 14 (1),61
12.	2019/11	Evaluation of critical flicker-fusion frequency measurement methods using a touchscreen-based visual temporal discrimination task in the behaving mouse │ Neuroscience Research │ 148,28-33
13.	2019/07	Gene delivery to cone photoreceptors by subretinal injection of rAAV2/6 in the mouse retina. │ Biochem. Biophys. Res. Commun. │ 515 (1),222-227頁
14.	2019/03	Adeno Associated Virus (AAV) as a tool for clinical and experimental delivery of target genes into the mammalian retina │ Biol. Pharm. Bull.(Review as current topics) │ 42 (3),343-347
15.	2018/05	Different activity patterns in retinal ganglion cells of TRPM1 and mGluR6 knockout mice. │ BioMed Research International │ 2018 (ID 2963232),1-6
16.	2018/05	病変網膜における自発振動活動発生メカニズム │ 薬学雑誌 │ 138 (5),685-692
17.	2018/05	網膜発生過程におけるON型双極細胞と病変網膜の電気生理学的解析 │ 薬学雑誌 │ 138 (5),679-684
18.	2018/05	網膜における生理・病態解明と治療開発への新展開 │ 薬学雑誌 │ 138 (5),667-668
19.	2017/02	Simulation Analysis of Phototransduction Systems in Rods and Cones │ BIOPHYSICAL JOURNAL │ 112 (3),531A-531A頁
20.	2016/09	Touchscreen-based visual temporal discrimination task in the behaving mouse by the constant method │ INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE │ 57 (12)
21.	2016/05	Expression of Quaking RNA-Binding Protein in the Adult and Developing Mouse Retina. │ PLOS ONE │ 11 (5),e0156033
22.	2014/08	Reproducing retinal rod bipolar cell light response by mathematical model including neurotransmitter receptors │ Conf Proc IEEE Eng Med Biol Soc. │ 2014,6116-9
23.	2014/06	杆体・錐体視細胞光応答機構初期過程モデルによる視物質ートランスデューシン間シグナル増幅現象の再現 │ 生体医工学 │ 52 (3),145-155
24.	2014/03	夜盲を引き起こす夜盲症と網膜色素変性症 │ ファルマシア │ 50 (3),222-226
25.	2012/11	Depolarizing Bipolar Cell Dysfunction due to a Trpm1 Point Mutation. │ J Neurophysiol │ 108 (9),2442-51
26.	2012	mGluR6 deletion renders the TRPM1 channel in retina inactive. │ J Neurophysiol │ 107 (3),948-57
27.	2011/08	miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression │ Nat. Neurosci. │ 14 (9),1125-34
28.	2011/07	A role for nyctalopin, a small leucine rich repeat protein, in localizing the TRPM1 channel to retinal depolarizing bipolar cell dendrites． │ J. Neurosci. │ 31 (27),10060-6
29.	2011	Spatially arranged microelectrode probes for multi-site electroretinogram recordings in the isolated mouse retina │ NEUROSCIENCE RESEARCH │ 71,E414-E414頁
30.	2010/08	TRPM1: A vertebrate TRP channel responsible for retinal ON bipolar function │ Cell Calcium │ 48 (2-3),95-101
31.	2010/03	TRPM1 mutations are associated with the complete form of congenital stationary night blindness │ Mol. Vis. │ 16,425-37
32.	2010/02	Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes. │ FEBS Letter │ 584 (4),753-758
33.	2010/01	TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade │ Proc.Natl. Acad. Sci. USA │ 107 (1),332-337
34.	2008/03	網膜視細胞の細胞極性と細胞内オルガネラの制御 │ 生化学 │ 80 (3),224-232-232頁
35.	2008	The functional analysis of TRPM1 in mammalian retinal bipolar cells │ NEUROSCIENCE RESEARCH │ 61,S59-S59頁
36.	2008	Regulation of cell polarity and intracellular organelles in retinal photoreceptor cells │ Seikagaku │ 80 (3),224-32
37.	2007/12	Functional roles of Otx2 transcription factor in postnatal mouse retinal development │ Mol Cell. Biol. │ 27 (23),8318-8329頁
38.	2006/03/16	Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells. │ BMC Dev. Biol. │ 6 (15),1-17
39.	2006	Molecular control of vertebrate retinal photoreceptor development │ NEUROSCIENCE RESEARCH │ 55,S18-S18頁
40.	2005/11	Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina. │ J Neurosci. │ 25 (44),10290-10298
41.	2005/09	aPKC lambda is essential for photoreceptor morphogenesis and total retinal lamination │ MECHANISMS OF DEVELOPMENT │ 122,S99-S99頁
42.	2005/05	網膜視細胞の極性と全層構造形成におけるPKCλの役割 │ 日本発生生物学会大会発表要旨集 │ 38th,112
43.	2004/06	Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression │ J Biol Chem. │ 279 (40),41504-41511
44.	2003/11	Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. │ Nat Neurosci. │ 6 (12),1255-1263
45.	2003/11	Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. │ Nat Neurosci. │ 6 (12),1255-1263-1263頁
46.	2003/09	Bilaterally increased VEGF-levels in muscles during experimental unilateral callus distraction │ JOURNAL OF ORTHOPAEDIC RESEARCH │ 21 (5),805-812頁
47.	2002	A role for iNOS in LPS-induced hyperglycemia and insulin resistance: evidence from specific iNOS inhibitor, aminoguanidine. │ Am. J. Physiol. │ 282 (2),E386-94
48.	2002/03	The mouse Crx 5'-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells. │ J Neurosci. │ 22 (5),1640-1647
49.	2002	Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses. │ Clin Exp Metastasis. │ 19 (8),717-725
50.	2002/03	Solid stress facilitates spheroid formation: potential involvement of hyaluronan │ BRITISH JOURNAL OF CANCER │ 86 (6),947-953頁
51.	2002	A role for iNOS in LPS-induced hyperglycemia and insulin resistance: evidence from specific iNOS inhibitor, aminoguanidine. │ Am. J. Physiol. │ 282 (2),E386-94
52.	2001/03	The Crx 5' upstream transgene sequence directs a cell-specific and developmentally regulated expression in photoreceptor cells. │ INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE │ 42 (4),S734-S734頁
53.	2000/11	網膜の細胞運命決定の分子機構－多様な神経細胞の運命はいかにして決定されるか │ 細胞工学 │ 19 (11),1692-1700頁
54.	2000/10	Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions │ Cancer Res. │ 60 (19),5565-5570
55.	2000/04	The orthotopic microenvironment promotes tumor growth and VEGF121 expression in human pancreatic adenocarcinoma. │ GASTROENTEROLOGY │ 118 (4),A1415-A1415頁
56.	2000/03	Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors. │ Cancer Res. │ 33 (1-2),710-711-6252頁
57.	2000/03	Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors. │ Cancer Res. │ 33 (1-2),710-711
58.	1999/12/15	Spermine induction of apoptosis in metastatic prostate carcinoma. │ Cancer Res. │ 59 (24),6019-12
59.	1999/11	Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin │ J Invest Dermatol. │ 113 (5),838-842
60.	1998/12	Role of sialylglycoconjugate(s) in the initial phase of metastasis of liver-metastatic RAW117 lymphoma cells. │ Jpn J Cancer Res │ 89 (12),1296-1305頁
61.	1998/10/01	転移性癌細胞の細胞交通 │ 実験医学 │ 16 (16)
62.	1998/05/08	How platelet aggregation affects B16BL6 melanoma cell trafficking │ FEBS Letters │ 427 (2),286-290頁
63.	1998/04	Corticotropin releasing hormone is a proangiogenic cytokine │ JOURNAL OF INVESTIGATIVE DERMATOLOGY │ 110 (4),518-518頁
64.	1997/08/15	Tumor cells with organ-specific metastatic ability show distinctive trafficking in vivo: analyses by positron emission tomography and bioimaging. │ Cancer Res. │ 57 (16),3612-3619
65.	1997/03	Application of liposomes for cancer metastasis │ ADVANCED DRUG DELIVERY REVIEWS │ 24 (2-3),215-223頁
66.	1997	Effective inhibition of metastasis by liposomal Arg- Gly-Asp analogs │ Drug Delivery System │ 12 (1),13-18頁
67.	1996/08/01	転移性癌細胞の生体内動態におけるインテグリンの関与 : PETを用いた解析 │ 日本分子生物学会年会プログラム・講演要旨集 │ 19,648-648頁
68.	1996/03	癌細胞の標的臓器微小管内への着床に及ぼすシアリルルイスX(SLex)およびRGDS誘導体の効果とその機序の解析 │ 日本薬学会年会要旨集 │ 116年会 (3),62-62頁
69.	1996/03	転移性癌細胞の生体内動態におけるインテグリンの関与 PETを用いた解析 │ 日本薬学会年会要旨集 │ 116年会 (3),122-122頁
70.	1996/03	Functional role of sialyl Lewis X and fibronectin-derived RGDS peptide analogue on tumor-cell arrest in lungs followed by extravasation │ INTERNATIONAL JOURNAL OF CANCER │ 65 (6),833-839頁
71.	1996	Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs. │ Life Sci. │ 58 (24),2263-2270頁
72.	1996/03/24	(博士取得論文)転移性癌細胞の生体内動態の非侵襲的解析－ポジトロン断層法のインビボ生化学への応用－ │ 学位論文 │
73.	1995/09/13	Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties. │ Biochim Biophys Acta. │ 1238,99-106頁
74.	1994/03	Positron emission tomography analysis of metastatic tumor cell trafficking. │ Cancer Res. │ 54 (10),2573-2576頁