研究者学術情報データベース

ミハラ　ヒサアキ
三原　久明
MIHARA Hisaaki

所属生命科学部生物工学科

職名教授

論文
1.	2025/01	Structural insights into the mechanism underlying the dual cofactor specificity of glyoxylate reductase from Acetobacter aceti in the β-hydroxyacid dehydrogenase family. │ Biochimica et biophysica acta. Proteins and proteomics │ 1873 (1),141051
2.	2024/08	Comparative studies on substrate specificity of succinic semialdehyde reductase from Gluconobacter oxydans and glyoxylate reductase from Acetobacter aceti. │ Bioscience, biotechnology, and biochemistry │ 88 (9),1069-1072
3.	2024/04/03	Effects of genetic disruption in thioredoxin and glutathione systems on selenium nanoparticle formation, selenite sensitivity, and selenoprotein biosynthesis in Escherichia coli │ Metallomics Research │ 4 (1),reg14-reg20頁
4.	2024/03/20	Selenium Nanoparticles Synthesized and Stabilized by Fungal Extract Exhibit Enhanced Bioactivity │ Journal of Cluster Science │ 35 (5),1425-1437頁
5.	2023/01/17	Comparison of Nutritional Availability of Biogenic Selenium Nanoparticles and Chemically Synthesized Selenium Nanoparticles │ Biological Trace Element Research │ 201 (10),4861-4869頁
6.	2023	生態系においてセレン循環を駆動する微生物 │ 金属 │ 93,162-168頁
7.	2023	必須微量元素セレンの微生物による多彩な代謝 │ ファルマシア │ 59 (3),185-189頁
8.	2022/09/20	Group II truncated haemoglobin YjbI prevents reactive oxygen species-induced protein aggregation in Bacillus subtilis │ eLife │ 11 (e70467)
9.	2021/03	Medicinal plant extracts protect epithelial cells from infection and DNA damage caused by colibactin-producing Escherichia coli, and inhibit the growth of bacteria. │ Journal of applied microbiology │ 130 (3),769-785
10.	2021/08	Complete Genome Sequence of Pseudomonas stutzeri Strain F2a, Isolated from Seleniferous Soil. │ Microbiology Resource Announcements │ 10 (33),e0063121
11.	2021/10	Initial Step of Selenite Reduction via Thioredoxin for Bacterial Selenoprotein Biosynthesis. │ International Journal of Molecular Sciences │ 22 (20)
12.	2021/12	Overexpression and characterization of Escherichia coli dihydropyrimidine dehydrogenase: a four iron-sulphur cluster containing flavoprotein. │ Journal of Biochemistry │ 170 (4),511-520
13.	2023/01/17	Comparison of Nutritional Availability of Biogenic Selenium Nanoparticles and Chemically Synthesized Selenium Nanoparticles. │ Biological Trace Element Research │
14.	2021/04/29	Genetic analysis of tellurate reduction reveals the selenate/tellurate reductase genes ynfEF and the transcriptional regulation of moeA by NsrR in Escherichia coli. │ Journal of Biochemistry │ 169 (4),477-484頁
15.	2020/11	Characterization of a novel class of glyoxylate reductase belonging to the β-hydroxyacid dehydrogenase family in Acetobacter aceti. │ Bioscience, Biotechnology, and Biochemistry │ 84 (11),2303-2310頁
16.	2019/06	Selenite uptake by outer membrane porin ExtI and its involvement in the subcellular localization of rhodanese-like lipoprotein ExtH in Geobacter sulfurreducens │ Biochem Biophys Res Commun │ 516 (2),474-479
17.	2019	Effect of ΔiscS deficiency on current generation of E. coli in Microbial Fuel Cells │ Advances in Natural and Applied Sciences │ 13 (1),15-21
18.	2019	High Performance Activated Carbon Paper-Based electrode for Microbial Fuel Cells │ Advances in Natural and Applied Sciences │ 13 (1),7-14
19.	2020/10	Complete Genome Sequence of an Acetic Acid Bacterium, Acetobacter aceti JCM20276. │ Microbiology resource announcements │ 9 (42)
20.	2018/11	毒か？栄養素か？　必須微量元素セレンの生物学 │ 海洋科学研究 │ 31 (2),95-100
21.	2018/06	Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis │ Biochim Biophys Acta │ 1862 (11),2433-2440
22.	2018/03	Characterization of a Novel Porin-Like Protein, ExtI, from Geobacter sulfurreducens and Its Implication in the Reduction of Selenite and Tellurite │ Int J Mol Sci │ 19 (3),809
23.	2020/06	Apolipoprotein E-mediated regulation of selenoprotein P transportation via exosomes. │ Cellular and molecular life sciences : CMLS │ 77 (12),2367-2386
24.	2017/09	Selective fluorescence detection method for selenide and selenol using monochlorobimane │ Anal Biochem │ 532,1-8
25.	2017/02	鉄硫黄クラスターおよびセレンタンパク質生合成とその分子機構 │ 硫酸と工業 │ 70 (2),23-28
26.	2017	Identification of selenomethionine, selenocysteine, and Se-methylselenocysteine in the selenium-enriched common ice plant │ Biomed. Res. Trace Elem. │ 28 (3),135-142
27.	2016/12	Relationship between the synthesis of glycosphingolipids and phospholipids and mycelial growth in Neurospora crassa │ Trace Nutr. Res. │ 33,13-20
28.	2016/10	A non-radioactive assay for selenophosphate synthetase activity using recombinant pyruvate pyrophosphate dikinase from Thermus thermophilus HB8 │ Biosci. Biotechnol. Biochem. │ 80 (10),1970-1972
29.	2016/03	Purification and properties of 4-methyl-5-hydroxyethylthiazole kinase from Escherichia coli │ Biosci. Biotechnol. Biochem. │ 80 (3),514-517
30.	2015/03	L-ピペコリン酸およびL-プロリンの生成に関わる多機能性酵素 │ 生化学 │ 87,326-332
31.	2015	Functional expression of L-lysine alpha-oxidase from Scomber japonicus in Escherichia coli for one-pot synthesis of L-pipecolic acid from DL-lysine │ Appl. Microbiol. Biotechnol. │ (99),5045-5054
32.	2015	Heterologous expression of L-lysine alpha-oxidase from Scomber japonicus in Pichia pastoris and functional characterization of the recombinant enzyme │ J Biochem │ (157),201-210
33.	2015	Purification and properties of glycine oxidase from Pseudomonas putida KT2440 │ J. Nutr. Sci. Vitaminol. │ 61,506-510
34.	2014/08	Glutathione Contributes to the Efflux of Selenium from Hepatoma Cells │ Biosci. Biotechnol. Biochem. │ 78 (8),1376-1780
35.	2014/05	Characterization of a thermostable 2, 4-diaminopentanoate dehydrogenase from Fervidobacterium nodosum Rt17-B1 │ J. Biosci. Bioeng. │ 117 (5),551-556
36.	2014/01	Global identification of genes affecting iron-sulfur cluster biogenesis and iron homeostasis │ J. Bacteriol. │ 196 (6),1238-1249
37.	2014	Effects of sugars and salt on the production of glycosphingolipids in Mariannaea elegans │ Trace Nutr. Res. │ 31,37-44
38.	2013/04	Novel neogala-series glycosphingolipids with a terminal glucose residue from the fungus Mariannaea elegans │ Biosci. Biotechnol. Biochem. │ 77,754-759
39.	2012/07	Pseudomonas putida PydR, a RutR-like transcriptional regulator, represses the dihydropyrimidine dehydrogenase gene in the pyrimidine reductive catabolic pathway │ J. Biochem. │ 152,341-346
40.	2012	Effects of a supernatant from Aspergillus oryzae culture on the regulation of crassulacean acid metabolism (CAM) and pinitol biosynthesis in the common ice plant, Mesembryanthemum crystallinum L. │ Trace Nutr. Res. │ 29,51-57
41.	2012	セレンディピティ │ バイオサイエンスとインダストリー │ 70,144
42.	2011	硫黄・セレン供給酵素群による含硫・含セレンバイオファクターの生成機構 │ バイオサイエンスとインダストリー │ 69,471-475
43.	2011	Bacterial cysteine desulfurases: versatile key players in biosynthetic pathways of sulfur-containing biofactors │ Appl Microbiol Biotechnol │ 91,47-61
44.	2011	Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil │ J. Bacteriol. │ 193,989-993
45.	2011	Favourable effects of eicosapentaenoic acid on the late step of the cell division in a piezophilic bacterium, Shewanella violacea DSS12, at high-hydrostatic pressures │ Environ. Microbiol. │ 13,2293-2298
46.	2011	Identification of novel mammalian phospholipids containing threonine, aspartate, and glutamate as the base moiety │ J Chromatogr B Analyt Technol Biomed Life Sci │ 879,3296-3302
47.	2011	Mammalian selenocysteine lyase is involved in selenoprotein biosynthesis │ J Nutr Sci Vitaminol │ 57,298-305
48.	2011	Selenite Reduction by the Thioredoxin System: Kinetics and Identification of Protein-Bound Selenide │ Biosci Biotechnol Biochem │ 75,1184-1187
49.	2011	Structure and function of selenocysteine lyase and cysteine desulfurase │ Amino Acids │ 41,S77-S78
50.	2011	鉄硫黄クラスター・セレンタンパク質生合成を司る酵素 │ 生化学 │ 83,1003-1015
51.	2010	The distribution of phosphatidyl-D-serine in the rat │ Biosci. Biotechnol. Biochem. │ 74,1953-1955
52.	2010	IscS Functions as a Primary Sulfur-donating Enzyme by Interacting Specifically with MoeB and MoaD in the Biosynthesis of Molybdopterin in Escherichia coli │ J. Biol. Chem. │ 285,2302-2308
53.	2010	Kenji Soda--researching enzymes with the spirit of an alpinist │ J Biochem │ 148,371-379
54.	2010	Reaction Mechanism and Molecular Basis for Selenium/Sulfur Discrimination of Selenocysteine Lyase │ J. Biol. Chem. │ 285,12133-12139
55.	2009	X-Ray Crystallographic and Mutational Studies of Fluoroacetate Dehalogenase from Burkholderia sp Strain FA1 │ J. Bacteriol. │ 191,2630-2637
56.	2009	Crystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombe │ J. Biol. Chem. │ 284,25944-25952
57.	2009	Eicosapentaenoic acid plays a beneficial role in membrane organization and cell division of a cold-adapted bacterium, Shewanella livingstonensis Ac10 │ J. Bacteriol. │ 191,632-640
58.	2009	Identification of proteins interacting with selenocysteine lyase │ Biosci. Biotechnol. Biochem. │ 73,1230-1232
59.	2009	Occurrence of phosphatidyl-D-serine in the rat cerebrum │ Biochem. Biophys. Res. Commun. │ 382,415-418
60.	2009	Selenocysteine is Selectively Taken Up by Red Blood Cells │ Biosci Biotechnol Biochem. │ 73,2746-2748
61.	2009	Serine racemase with catalytically active lysinoalanyl residue │ J. Biochem. │ 145,421-424
62.	2008	モリブドプテリン生合成におけるシステインデスルフラーゼIscSの役割 │ ビタミン │ 82,645-650
63.	2008	Characterization of human selenocysteine synthase involved in selenoprotein biosynthesis │ Biomed. Res. Trace Elem. │ 19,80-83
64.	2008	Functional analysis of two homologous mouse selenophosphate synthetases │ Biomed. Res. Trace Elem. │ 19,76-79
65.	2008	Investigation of the Roles of Cysteine Desulfurases in the Molybdopterin Synthesis in Escherichia coli │ Trace Nutri. Res. │ 25,152-157
66.	2008	N-アルキルアミノ酸と環状イミノ酸の不斉合成に利用できる酵素 │ ファインケミカル │ 37,12-21
67.	2008	Selenite Assimilation into Formate Dehydrogenase H Depends on Thioredoxin Reductase in Escherichia coli │ J. Biochem. │ 143,467-473
68.	2008	The iscS gene deficiency affects the expression of pyrimidine metabolism genes │ Biochem. Biophys. Res. Commun. │ 372,407-411
69.	2008	Thioredoxin Reductase 1 Is Important for Selenoprotein Biosynthesis in HeLa Cells │ Biomed. Res. Trace Elem. │ 19,84-87
70.	2007	セレンタンパク質 │ 金属 │ 77,262-268
71.	2007	Biochemical and genetic analysis of the γ-resorcylate (2,6-dihydroxybenzoate) catabolic pathway in Rhizobium sp strain MTP-10005: Identification and functional analysis of its gene cluster │ J. Bacteriol. │ 189,1573-1581
72.	2007	Mining prokaryotic genomes for unknown amino acids: a stop-codon-based approach │ BMC Bioinformatics │ 8,225
73.	2007	Prediction of missing enzyme genes in a bacterial metabolic network - Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa │ FEBS J. │ 274,2262-2273
74.	2007	シュードモナスのリジン分解経路におけるミッシング酵素の同定と解析 │ ビタミン │ 81,595-600
75.	2006	代謝経路データベース上のミッシング酵素の同定 -Identification of missing enzymes in metabolic pathway databases- │ バイオサイエンスとインダストリー │
76.	2006	Enzymatic synthesis of cyclic amino acids by N-methyl-L-amino acid dehydrogenase from Pseudomonas putida │ Tetrahedron-Asymmet. │ 17,1775-1779
77.	2006	Enzymatic synthesis of L-pipecolic acid by Δ1-piperideine-2-carboxylate reductase from Pseudomonas putida │ Biosci. Biotechnol. Biochem │
78.	2006	N-メチル-L-アミノ酸とL-ピペコリン酸の合成酵素 -An enzyme synthesizing N-methyl-L-amino acid and pipecolic acid- │ バイオサイエンスとインダストリー │
79.	2006	Selenoprotein biosynthesis and selenium-specific enzymes │ Biomed. Res. Trace Elem │
80.	2006	セレン化合物とピリドキサール5´-リン酸酵素の生化学 │ Vitamins [ビタミン] │
81.	2005	The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline │ J. Biol. Chem │
82.	2005	A new family of NAD(P)H-dependent oxidoreductases distinct from conventional Rossmann-fold proteins │ J. Biosci. Bioeng │
83.	2005	Crystal structures of Δ1-piperideine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases - Conformational change, substrate recognition, and stereochemistry of the reaction │ J. Biol. Chem │
84.	2005	N-Methyl-L-amino acid dehydrogenase from Pseudomonas putida - A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily │ FEBS J │
85.	2005	Protein interaction between selenophosphate synthetase and IscS │ Biomed. Res. Trace Elem │
86.	2005	RNAi-mediated knock down of mammalian selenocysteine lyase │ Biomed. Res. Trace Elem │
87.	2004	Expression analysis of mammalian selenocysteine lyase │ Biomed. Res. Trace Elem │
88.	2004	Enzymatic synthesis of N-methyl-L-phenylalanine by a novel enzyme, N-methyl-L-amino acid dehydrogenase, from Pseudomonas putida │ Tetrahedron: Asymmet │
89.	2003	鉄硫黄クラスター形成にかかわるピリドキサル酵素の機能、構造、触媒機構 │ ビタミン │
90.	2003	A novel regulatory function of selenocysteine lyase, a unique catalyst to modulate major urinary protein │ J. Mol. Cat. B-Enzym │
91.	2003	Assembly of iron-sulfur clusters mediated by cysteine desulfarases, IscS, CsdB and CSD, from Escherichia coli │ Biochim. Biophys. Acta │
92.	2003	Characterization of a NifS-like chloroplast protein from Arabidopsis. Implications for its role in sulfur and selenium metabolism │ Plant Physiology │
93.	2003	Effects of selenium deficiency on the expression of selenoprotein mRNAs in mouse brain │ Biomed. Res. Trace Elem │
94.	2003	Enhanced selenium tolerance and accumulation in transgenic Arabidopsis expressing a mouse selenocysteine lyase │ Plant Physiol │
95.	2002	セレンの生化学 │ ビタミン │
96.	2002	Bacterial cysteine desulfurases: their function and mechanisms │ Appl. Microbiol. Biotechnol │
97.	2002	Characterization of a NifS-Like chloroplast protein from Arabidopsis. Implications for its role in sulfur and selenium metabolism │ Plant Physiol │
98.	2002	Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: Implications for the mechanism of iron-sulfur cluster assembly │ Proc. Natl. Acad. Sci. USA │
99.	2002	in The 19th Symposium on Trace Nutrients Research [微量栄養素研究] │
100.	2002	Network of protein-protein interactions among iron-sulfur cluster assembly proteins in Escherichia coli │ J. Biochem │
101.	2002	Protein Interaction between Selenocysteine Lyase and MUP-I │ Biomed. Res. Trace Elem │
102.	2002	Selenocysteine lyase from mouse liver │ Method Enzymol │
103.	2002	Structure of external aldimine of Escherichia coli CsdB, an IscS/NifS homolog: Implications for its specificity toward selenocysteine │ J. Biochem │
104.	2002	The iscS gene is essential for the biosynthesis of 2-selenouridine in tRNA and the selenocysteine-containing formate dehydrogenase H │ Proc. Natl. Acad. Sci. USA │
105.	2001	Role of Cysteine Desulfurase in the Biosynthesis of Formate Dehydrogenase H Containing Mo, Molybdopterin, Selenocysteine, and Fe4S4 Cluster │ Biomed. Res. Trace Elem │
106.	2001	in The 18th Symposium on Trace Nutrients Research [微量栄養素研究] │
107.	2001	Removal of soluble selenium by a selenate-reducing bacterium Bacillus sp. SF-1 │ Biofactors │
108.	2000	cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase - Candidate for selenium delivery protein in selenoprotein synthesis │ J. Biol. Chem │
109.	2000	Escherichia coli NifS-like proteins provide selenium in the pathway for the biosynthesis of selenophosphate │ J. Biol. Chem │
110.	2000	Gene cloning, purification, and characterization of two cyanobacterial NifS homologs driving iron-sulfur cluster formation │ Biosci. Biotechnol. Biochem │
111.	2000	in The 17th Symposium on Trace Nutrients Research [微量栄養素研究] │
112.	2000	Kinetic and mutational studies of three NifS homologs from Escherichia coli: Mechanistic difference between L-cysteine desulfurase and L-selenocysteine lyase reaction │ J. Biochem │
113.	2000	Structure of a NifS homologue: X-ray structure analysis of CsdB, an Escherichia coli counterpart of mammalian selenocysteine lyase │ Biochemistry │
114.	1999	A nifS-like gene, csdB, encodes an Escherichia coli counterpart of mammalian selenocysteine lyase - Gene cloning, purification, characterization and preliminary x-ray crystallographic studies │ J. Biol. Chem │
115.	1999/09	(博士取得論文)Enzymological Studies of Cysteine Desulfurase and Selenocysteine Lyase │
116.	1997	Cysteine sulfinate desulfinase, a NIFS-like protein of Escherichia coli with selenocysteine lyase and cysteine desulfurase activities - Gene cloning, purification, and characterization of a novel pyridoxal enzyme │ J. Biol. Chem │
117.	1999	in The 16th Symposium on Trace Nutrients Research [微量栄養素研究] │
118.	1997	Cysteine sulfinate desulfinase, a NIFS-like protein of Escherichia coli with selenocysteine lyase and cysteine desulfurase activities. Gene cloning, purification, and characterization of a novel pyridoxal enzyme │ ICR Annu. Report │
119.	1995	A new possibility to treatment of AIDS by selenium [セレンによるAIDS治療の可能性] │ Vitamins │
120.	1994	Multiple Proline Substitutions Cumulatively Thermostabilize Bacillus cereus ATCC7064 Oligo-1,6-Glucosidase - Irrefragable Proof Supporting the Proline Rule │ Eur. J. Biochem │