研究者学術情報データベース

キタムラ　ヨシヒサ
北村　佳久
KITAMURA YOSHIHISA

所属薬学部創薬科学科

職名教授

論文
1.	2022	Lipoxin A4 receptor stimulation attenuates neuroinflammation in a mouse model of intracerebral hemorrage. │ Brain Sciences │ 12,162 (共著)
2.	2022	Nicotinic acetylcholine receptors and microglia as therapeutic and imaging targets in Alzheimer’s disease │ Molecules │ 27,2780 (共著)
3.	2021/01/19	MEK/ERK signaling regulates reconstitution of the dopaminergic nerve circuit in the planarian Dugesia japonica │ Neurochemical Research │ (共著)
4.	2021	Kaempferol has potent protective and antifibrillogenic effectsfor α-synuclein neurotoxicity in vitro. │ Molecular Sciences │ 22 (21),11484 (共著)
5.	2020/11	Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke. │ J. Pharmacol. Sci., │ 144 (3),183-187頁 (共著)
6.	2020/08	Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage. │ Int. Immunopharmacol. │ 85,106678 (共著)
7.	2020/07	Mouse bone marrow-derived microglia-like cells secrete transforming growth factor-beta1 and promote Microglial amyloid-beta phagocytosis and reduction of brain amyloid-beta. │ Neuroscience, │ 438,217-228頁 (共著)
8.	2020/01	Peripheral blood-derived microglia-like cells decrease amyloid-beta burden and ameliorate cognitive impairment in a mouse model of Alzheimer’s disease. │ J. Alzheimer’s Dis. │ 73 (01),413-429 (共著)
9.	2018/08	Bone-marrow-derived microglia-like cells ameliorate brain amyloid pathology and cognitive impairment in a mouse model of Alzheimer's disease. │ J. Alzheimer’s Dis. │ 64 (2),563–585 (共著)
10.	2018/02	Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. │ Neurobiology of Aging │ 62,197-209 (共著)
11.	2017/07	Fluorodopa is a promising fluorine-19 MRI probe for evaluating striatal dopaminergic function in a rat model of Parkinson's disease. │ J. Neurosci. Res. │ 95 (7),1485-1494 (共著)
12.	2017/07	Induced-pluripotent-stem-cell-derived primitive macrophages provide a platform for modeling tissue-resident macrophage differentiation and function. │ Immunity │ 47 (1),183-198 (共著)
13.	2017/05	DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders. │ Biol. Pharm. Bull. │ 40 (5),548-552 (共著)
14.	2017/02	Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala. │ Pharmacol. Biochem. Behav. │ 153,1-11 (共著)
15.	2017/01	Effects of a DJ-1-binding compound on spatial learning and memory impairment in a mouse model of Alzheimer's disease. │ J. Alzheimer’s Dis. │ 55 (1),67-72 (共著)
16.	2016/06	小胞体機能異常による疾患発症機構と創薬への展開. │ 薬学雑誌 │ 136 (6),799-800 (共著)
17.	2016	Therapeutic effects of mesenchymal stem cells for Parkinson's disease. │ Ann. Neurodeg. Dis. │ 1 (1),1002 (共著)
18.	2016	α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior. │ Neurochem. Int. │ 94,74-81 (共著)
19.	2015/05	DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. │ J. Pharmacol. Sci. │ 127 (3),305-310 (共著)
20.	2015/01	Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components. │ Biochem. Bioph. Res. Co. │ 456 (3),768-773 (共著)
21.	2015/01	Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. │ J. Alzheimer's Dis. │ 44 (2),409-423 (共著)
22.	2014	Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease. │ PLoS One │ 9 (5),e94576 (1-10) (共著)
23.	2014	Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica. │ Biochem. Bioph. Res. Co. │ 449 (4),412-418 (共著)
24.	2013	3-[(2,4-Dimethoxy) benzyl-idene]-anabaseine dihydrochloride protects against 6-hydroxy-dopamine-induced parkinsonian neurodegeneration through 7 nicotinic acetylcholine receptor stimulation in rats. │ J. Neurosci. Res. │ 91 (2),462-471 (共著)
25.	2013	Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice. │ J. Neurosci. Res. │ 91 (1),62-72 (共著)
26.	2013	ドパミン神経の保護および再生の多様性. │ ファルマシア │ 49,859-863 (共著)
27.	2012/09	Detoxification of 6-hydroxydopamine-induced dopaminergic neurodegeneration by 5,5-dimethyl-1-pyrroline N-oxide, a radical trapper, in hemiparkinsonian rats. │ Biol. Pharm. Bull. │ 35 (9),1603-1606頁 (共著)
28.	2012/05	Administration of rotenone enhanced voluntary alchohol drinking behavior in C57BL/6J mice. │ Leg. Med.-Tokyo │ 14 (5),229-238頁 (共著)
29.	2012/05	Effect of serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model. │ J. Pharmacol. Sci. │ 119 (1),10-19頁 (共著)
30.	2012	Microglial amyloid-β1-40 phagocytosis dysfunction is caused by high-mobility group box protein-1: Implications for the pathological progression of Alzheimer’s disease. │ Int. J. Alzheimer’s Dis. │ ,685739 (1-11) (共著)
31.	2012	Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer’s disease: tangle formation, amyloid-β, and microglia in Alzheimer’s disease. │ J. Pharmacol. Sci. │ 118 (3),331-337 (共著)
32.	2012	Protective effect of planarian DJ-1 against 6-hydroxydopamine-induced neurotoxicity. │ Neurosci. Res. │ 74 (3-4),277-283 (共著)
33.	2012	アミロイドβの代謝とアルツハイマー病. │ 内分泌・糖尿病・代謝内科 │ 34,204-209 (共著)
34.	2011	Detoxification of 6-hydroxydopamine-induced Parkinosnian neurodegeneration by G-CYPMPO, a novel radical trapper. │ Neurochem. Int. │ 58 (6),721-727 (共著)
35.	2011	Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson’s disease and stroke model rats. │ Molecular Neurodegeneration │ 6 (1),48 (1-19) (共著)
36.	2011	Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice. │ Biol. Pharm. Bull. │ 34,92-96 (共著)
37.	2011	Preparation and characterization of microglia-like cells derived from rat, mouse, and human bone marrow cells for therapeutic strategy of Alzheimer’s disease. │ J. Addict. Res. Ther. │ S5:001,1-5 (共著)
38.	2011	Protection against dopaminergic neurodegeneration in Parkinson’s disease–model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson’s disease–linked PARK7. │ J. Pharmacol. Sci. │ 117,189-203 (共著)
39.	2011	Regeneration of dopaminergic neurons after 6-hydroxydopamine-induced lesion in planarian brain. │ J. Neurochem. │ 119 (6),1217-1231 (共著)
40.	2011	アミロイドβタンパク質依存性アルツハイマー病病変の研究． │ 薬学雑誌 │ 131,3-11 (共著)
41.	2011	一枚の写真館. 想像から創造へ. │ 細胞工学 │ 30,1011 (共著)
42.	2010/10	ドパミン神経保護及び神経ネットワークの再構築. │ 薬学雑誌 │ 130 (10),1263-1272頁 (単著)
43.	2010/06	Analysis of motor function modulated by cholinergic neurons in planarian Dugesia japonica. │ Neuroscience │ 168 (1),18-30頁 (共著)
44.	2010	Galantamine-induced amiloid-beta clearance mediated via stimulation of microglial nicotinic acetylcholine receptors. │ J. Biol. Chem. │ 285,40180-40191 (共著)
45.	2010	Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-β generation. │ J. Neurosci. │ 30,3924-3932 (共著)
46.	2010	The 6-hydroxydopamine-induced nigrostriatal neurodegeneration produces microglia-like NG2 glial cells in the rat substantia nigra. │ Glia │ 58,1686-1700 (共著)
47.	2009/12	Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice. │ Neurochem. Int. │ 55 (8),760-767頁 (共著)
48.	2009/12	The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues. │ J. Histochem. Cytochem. │ 57 (12),1121-1126頁 (共著)
49.	2009/11	Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson’s disease-linked PARK7. │ Int. J. Mol. Sci. │ 10 (11),4789-4804頁 (共著)
50.	2009/10	Identification of a novel planarian G-protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes. │ Biol. Pharm. Bull. │ 32 (10),1672-1677頁 (共著)
51.	2009/04	Aβストレスとミクログリア. │ 分子精神医学 │ 9,206-207頁 (共著)
52.	2009/03	Neuroprotective function in brain microglia. │ Curr. Aneasth. Crit. Care │ 20 (3),142-147頁 (共著)
53.	2009/03	Protection against oxidative stress-induced neurodegeneration by a modulator for DJ-1, the wild-type of familial Parkinson’s disease-linked PARK7. │ J. Pharmacol. Sci. │ 109 (3),463-468頁 (共著)
54.	2009/02	Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson’s disease models. │ J. Neurosci. Res. │ 87 (2),576-585頁 (共著)
55.	2009/01	Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. │ Oxid. Med. Cell. Longev. │ 2 (1),36-42頁 (共著)
56.	2009	Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells. │ Stem Cells Dev. │ 18,629-639 (共著)
57.	2009	Involvement of WAVE accumulation in Aβ/APP pathology-dependent tangle modification in Alzheimer’s disease. │ Am. J. Pathol. │ 175,17-24 (共著)
58.	2008/12	Characterization of tyramine beta-hydroxylase in planarian Dugesia japonica: cloning and expression. │ Neurochem. Int. │ 53 (6-8),184-192頁 (共著)
59.	2008/12	Synergistic effect of galantamine on nicotine-induced neuroprotection in hemi-parkinsonian rat model. │ Neurosci. Res. │ 62 (4),254-261頁 (共著)
60.	2008/08	Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells. │ Stem Cells Dev. │ 17 (4),641-651頁 (共著)
61.	2008/06	Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia japonica. │ Neuroscience │ 153 (4),1103-1114頁 (共著)
62.	2008/06	Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats. │ Biol. Pharm. Bull. │ 31 (6),1121-1130頁 (共著)
63.	2008/04	プラナリアにおける脳再生の分子機構とドパミン神経ネットワークの再構築. │ BRAIN and NERVE │ 60,307-317頁 (共著)
64.	2008/03	Recombinant human DJ-1 protein has a protective effect for dopaminergic neurons. │ Curr. Topics Pet. Prot. Res. │ 9,47-55頁 (共著)
65.	2008	DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. │ J. Cerebr. Blood F. Met. │ 28,563-578 (共著)
66.	2008	DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats. │ J. Neurochem. │ 105,2418-2434 (共著)
67.	2007/11	Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration. │ Eur. J. Neurosci. │ 26 (9),2458-2468頁 (共著)
68.	2007/09	Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica. │ Neurosci. Res. │ 59 (1),101-106頁 (共著)
69.	2007/06	Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. │ J. Neurochem. │ 101 (6),1491-1504頁 (共著)
70.	2007/02	Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats. │ FEBS. Lett. │ 581 (3),475-478頁 (共著)
71.	2007/02	家族性Parkinson病PARK7の原因遺伝子産物DJ-1のドパミン神経保護作用. │ 医学のあゆみ │ 221,194-195頁 (共著)
72.	2007	Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates. │ Dev. Neurobiol. │ 387,1059-1078 (共著)
73.	2006/12	Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus. │ Neurosci. Res. │ 56 (4),459-469頁 (共著)
74.	2006/11	Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells. │ J. Pharmacol. Sci. │ 102 (3),354-358頁 (共著)
75.	2006/10	Distribution of DJ-1, Parkinson’s disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemi-parkinsonian rat brain. │ J. Pharmacol. Sci. │ 102 (2),243-247頁 (共著)
76.	2006/10	Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells. │ Neurosci. Lett. │ 407 (1),74-79頁 (共著)
77.	2006/10	PARK7/DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model. │ Neurobiol. Dis. │ 24 (1),144-158頁 (共著)
78.	2006/07	Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain. │ Histol. Histopathol. │ 21 (7-9),705-711頁 (共著)
79.	2005/11	Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats. │ J. Neurochem. │ 95 (4),950-961頁 (共著)
80.	2005/10	Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats. │ Neurosci. Lett. │ 387 (3),151-156頁 (共著)
81.	2005/08	グリア細胞と脳疾患：アルツハイマー病. │ Clinical Neuroscience │ 23,203-205頁 (共著)
82.	2005/08	神経変性疾患におけるグリア細胞のかかわり−ヘムオキシゲナーゼ-1の誘導と神経保護. │ 医学のあゆみ │ 215,3647-3651頁 (共著)
83.	2005/03	Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia. │ J. Neuroimmunol. │ 160 (1-2),92-101頁 (共著)
84.	2005/02	Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemi-parkinsonian rats. │ J. Pharmacol. Sci. │ 97 (2),203-211頁 (共著)
85.	2005/02	Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. │ J. Pharmacol. Sci. │ 97 (2),289-293頁 (共著)
86.	2004/12	Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenyl-pyridinium ion and rotenone. │ Biogenic Amines │ 17 (4-6),281-291頁 (共著)
87.	2004/12	ストレス蛋白質とミクログリアによるアミロイドβ貪食機能. │ 日本薬理学雑誌 │ 124,407-413頁 (共著)
88.	2004/09	High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. │ J. Neurosci. Res. │ 78 (6),880-891頁 (共著)
89.	2004/09	Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell- derived neurons. │ J. Pharmacol. Sci. │ 96 (1),53-64頁 (共著)
90.	2004/02	Intracerebroventricular injection of microglia protects against focal brain ischemia. │ J. Pharmacol. Sci. │ 94 (2),203-206頁 (共著)
91.	2004/02	ミクログリアとアルツハイマー病. │ 脳 21 │ 7,137-143頁 (共著)
92.	2004	Proteasome mediates dopaminergic neuronal degeneration and its inhibition causes alpha-synuclein inclusions. │ J. Biol. Chem. │ 279 (11),10710-10719頁 (共著)
93.	2003/08	Disease model: Parkinson’s disease. │ Trends Mol. Med. │ 9 (8),360-365頁 (共著)
94.	2003/08	Possible involvement of Wiskott-Aldrich syndrome protein (WASP) family in aberrant neuronal sprouting in Alzheimer’s disease. │ Neurosci. Lett. │ 346 (3),149-152頁 (共著)
95.	2003/07	Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in thapsigargin-induced apoptosis in human neuroblastoma SH-SY5Y cells. │ J. Pharmacol. Sci. │ 92 (3),228-236頁 (共著)
96.	2003/06	Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo. │ Neurosci. Lett. │ 344 (2),87-90頁 (共著)
97.	2003/06	Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model. │ J. Pharmacol. Sci. │ 92 (2),137-142頁 (共著)
98.	2003/06	Involvement of Wiskott- Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. │ J. Pharmacol. Sci. │ (共著)
99.	2003/06	Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists. │ Neurochem. Res. │ 28 (7),1035-1045頁 (共著)
100.	2003/04	Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta12,14 prostaglandin J2- sensitive microglial activation. │ J. Pharmacol. Sci. │ 91 (4),330-333頁 (共著)
101.	2003/02	Hyperbilirubinemia protects against focal ischemia in rats. │ J. Neurosci. Res. │ 71 (4),544-550頁 (共著)
102.	2003/02	Role of high mobility group-1 (HMG-1) in amyloid-beta homeostasis. │ Biochem. Bioph. Res. Co. │ 301 (3),699-703頁 (共著)
103.	2003/01	Stress proteins and glial functions: possible therapeutic targets for neurodegenerative disorders. │ Pharmacol. Therapeut. │ 97 (1),35-53頁 (共著)
104.	2002/12	Regulation of amyloid-beta clearance by stress proteins. │ 2,89-98頁 (共著)
105.	2002/11	Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. │ Neurosci. Lett. │ 333 (1),25-28頁 (共著)
106.	2002/11	Possible involvement of ER chaperone Grp78 on reduced formation of amyloid- deposits. │ Ann. NY Acad. Sci. │ 977,327-332頁 (共著)
107.	2002/11	Possible protective mechanisms of heme oxygenase-1 in the brain. │ Ann. NY Acad. Sci. │ 977,501-506頁 (共著)
108.	2002/04	Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. │ FASEB J. │ 16 (6),601-603頁 (共著)
109.	2002/03	Antiparkinsonian drugs and their neuroprotective effects. │ Biol. Pharm. Bull. │ 25 (3),284-290頁 (共著)
110.	2001/08	Decrease of tyrosine hydroxylase-, alpha-synuclein and parkin-positive neurons in the substantia nigra of MPTP-treated C57BL/6N mice. │ Biogenic Amines │ 16 (2),127-136頁 (共著)
111.	2001/06	Lipopolysaccharide-induced switch between retinoid receptor (RXR)alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia. │ J. Neurosci. Res. │ 64 (6),553-563頁 (共著)
112.	2001/04	Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia. │ Brain. Res. │ 898 (1),181-185頁 (共著)
113.	2001/04	Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole. │ Eur. J. Pharmacol. │ (共著)
114.	2001/03	『賢者の石』を求めて：錬金術から再生医学へ. │ 日本薬理学雑誌 │ 117 (3),214-215頁 (単著)
115.	2001/02	BiP/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia. │ Biochem. Bioph. Res. Co. │ 281 (1),6-10頁 (共著)
116.	2001/01	Effects of 15-deoxy-delta12,14 prostaglandin J2 and interleukin-4 in Toll-like receptor-4-mutant glial cells. │ Eur. J. Pharmacol. │ 411 (3),223-230頁 (共著)
117.	2000/11	The parkinsonian models: Invertebrates to mammals. │ Jpn. J. Pharmacol. │ 84 (3),237-243頁 (共著)
118.	2000/09	Aryl hydrocarbon receptor nuclear translocator (ARNT) is induced by kainic acid in hippocampal glial cells. │ Neurosci. Lett. │ 291 (2),117-120頁 (共著)
119.	2000/07	Increase of Bcl-2 protein in neuronal dendritic process of cerebral cortex and hippocampus by talipexole and pramipexole, antiparkinsonian drugs. │ Brain Res. │ 872 (1-2),236-241頁 (共著)
120.	2000/07	Interleukin-4-inhibited mRNA expression in mixed astrocyte and isolated rat microglail cultures. │ J. Neuroimmunol. │ (共著)
121.	1999/11	Endogenous adenosine protects CA1 neurons from kainic acid-induced neuronal cell loss in the rat hippocampus. │ Eur. J. Neurosci. │ 11 (10),3617-3625頁 (共著)
122.	1999/11	Low-affinity kainate receptor subunit-specific agonist, (2S,4R)-4-methylglutamate (SYM-2081), does not induce neuronal cell death in rat hippocampal formation. │ J. Brain Sci. │ 25 (1-2),3-10頁 (共著)
123.	1999/11	Phosphorylation of c-Jun and its localization with heme oxygenase-1 and cyclooxygenase-2 in CA1 pyramidal neurons after transient forebrain ischemia. │ J. Cerebr. Blood F. Met. │ 19 (11),1247-1255頁 (共著)
124.	1999/07	Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation. │ Brain Res. │ 836 (1-2),213-217頁 (共著)
125.	1999/06	Developmental expression of P-glycoprotein (multiple resistance gene product) in the rat brain. │ J. Neurobiol. │ 39 (3),383-392頁 (共著)
126.	1999/06	Expression of heme oxygenase-1 mediated by non-NMDA and metabotropic receptors in glial cells: Possible involvement of reactive oxygene species production and protein kinase C activation. │ Neuropharmacology │ 38 (6),825-834頁 (共著)
127.	1999/03	Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible NO synthase expression but increase heme oxygenase-1 expression in rat glial cells. │ Neurosci. Lett. │ 262 (2),129-132頁 (共著)
128.	1999/02	Induction of inducible heme oxygenase (HO-1) in the central nervous system: Is HO-1 helpful or harmful? │ Neurotox. Res. │ 1 (2),113-117頁 (共著)
129.	1999/02	Interferon-gamma plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus. │ Neurochem. Int. │ 34 (2),91-99頁 (共著)
130.	1999/01	Apoptotic cell death in neurons and glial cells: Implications for Alzheimer’s disease. │ Jpn. J. Pharmacol. │ 79 (1),1-5頁 (共著)
131.	1999/01	Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. │ Glia │ 25 (2),154-164頁 (共著)
132.	1999/01	Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer’s disease brains. │ Biochem. Bioph. Res. Co. │ 254 (3),582-586頁 (共著)
133.	1999/01	Kainic acid-induced activation of nuclear factor-kB in rat hippocampus. │ Exp. Brain Res. │ 124 (2),215-222頁 (共著)
134.	1998/12	Protective effects of anti-parkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells. │ Mol. Pharmacol. │ 54 (6),1046-1054頁 (共著)
135.	1998/11	Mechanism of selective moter neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection. │ Ann. Neurol. │ 44 (5),796-807頁 (共著)
136.	1998/10	Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse. │ Neurosci. Lett. │ 255 (1),57-60頁 (共著)
137.	1998/09	Protective effect of talipexole on MPTP-treated planarian, a unique parkinsonian worm model. │ Jpn. J. Pharmacol. │ 78 (1),23-29頁 (共著)
138.	1998/08	D-Serine content and D-[³H]serine binding in the brain regions of the senescence-accelerated mouse. │ Mech. Ageing Dev. │ 104 (2),115-124頁 (共著)
139.	1998/08	Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia. │ J. Cerebr. Blood F. Met. │ 18 (8),824-832頁 (共著)
140.	1998/08	Induction of plasminogen in rat hippocampal pyramidal neurons by kainic acid. │ Neurosci. Lett. │ 252 (2),119-122頁 (共著)
141.	1998/08	Kainic acid induction of heme oxygenase in vivo and in vitro. │ Neuroscience │ 85 (4),1223-1233頁 (共著)
142.	1998/07	ノックアウトマウスの機能解析における遺伝的背景の影響. │ 日本薬理学雑誌 │ 112 (1),71-72頁 (単著)
143.	1998/06	神経細胞死における組織プラスミノーゲンアクチベーター（tPA）の関与. │ 日本薬理学雑誌 │ 111 (6),394-395頁 (単著)
144.	1998/03	Induction of inducible nitric oxide synthase and heme oxygenase-1 in rat glial cells. │ Life Sci. │ 62 (17/18),414-415頁 (共著)
145.	1998/03	脳障害時におけるグリア細胞の活性化および機能解析. │ 日本薬理学雑誌 │ 111 (3),147-156頁 (単著)
146.	1998/02	In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: possible involvement of nitric oxide production from inducible nitric oxide synthase. │ Glia │ 22 (2),138-148頁 (共著)
147.	1998/01	Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer’s disease. │ Brain Res. │ 780 (2),260-269頁 (共著)
148.	1998/01	Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells. │ Neurochem Int. │ 32 (1),93-102頁 (共著)
149.	1997/11	Ameliorating effects of calcium/ magnesium lithospermate B on cognitive deficiencies in senescence-accelerated mouse. │ Kor. J. Gerontol. │ 7 (1),17-24頁 (共著)
150.	1997/10	Alteration of transcription factors NF-kB and STAT1 in Alzheimer’s disease brains. │ Neurosci. Lett. │ 237 (1),17-20頁 (共著)
151.	1997/10	Possible involvement of rapamycin-sensitive pathway in Bcl-2 expression in human neuroblastoma SH-SY5Y cells. │ Jpn. J. Pharmacol. │ 75 (2),195-198頁 (共著)
152.	1997/07	In vivo hypoxia-induced neuronal damage with an increase of neuronal nitric oxide synthase immunoreactivity in hippocampus. │ Exp. Neurol. │ 146 (1),57-66頁 (共著)
153.	1997/06	Effects of kyotorphin (L-tyrosyl- L-arginine) on the binding of [3H]NG-nitro-L-arginine to constitutive nitric oxide synthase. │ Neurochem. Int. │ 30 (6),605-611頁 (共著)
154.	1997/06	In vivo hypoxia-induced neuronal damage in dantate gyrus of rat hippocampus changes of NMDA receptors and the effect of MK-801. │ Neurochem. Int. │ 30 (6),605-611頁 (共著)
155.	1997/06	Stimulatory roles of muscarinic acetylcholine receptors on T-cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes. │ Mol. Pharmacol. │ 51 (6),1007-1014頁 (共著)
156.	1997/06	脳障害における細胞情報伝達機構：グリア細胞の役割 │ 医学のあゆみ │ 183 (6),414-415頁 (単著)
157.	1997/05	Inhibitory effects of talipexole and pramipexole on MPTP-induced dopamine reduction in the striatum of C57BL/6N mice. │ Jpn. J. Pharmacol. │ 74 (1),51-57頁 (共著)
158.	1997/03	5-Hydroxytryptamine-induced Ca²⁺-independent cGMP formation is mediated by nitric oxide in a nitric oxide synthase-independent manner in NG 108-15 cells. │ Neurosci. Res. │ 27 (3),229-233頁 (共著)
159.	1997/03	Changes of p53 in the brains of patients with Alzheimer’s disease. │ Biochem. Bioph. Res. Co. │ 232 (2),418-421頁 (共著)
160.	1997/03	N^G-Nitro-L-[³H]arginine binding properties of neuronal nitric oxide synthase in rat brain. │ Neurochem. Int. │ 30 (3),239-245頁 (共著)
161.	1997/03	Possible involvement of ADP-ribosylation of particular enzymes in cell death induced by nitric oxide in human neuroblastoma cells. │ Neurochem. Int. │ 30 (3),305-311頁 (共著)
162.	1997/02	Alterations in acetylcholine, NMDA, benzodiazepine receptors and protein kinase C in the brain of the senescence-accelerated mouse: an animal model useful for studies on cognitive enhancers. │ Behav. Brain Res. │ 83 (1-2),51-55頁 (共著)
163.	1997/01	aFGF, endogenous satiety substance, facilitates learning, memory and immune function in aging. │ Jpn. J. Physiol. │ 47 (Suppl. 1),S52-S54頁 (共著)
164.	1996/12	Ameliorating effects of Dan-Shen methanol extract on cognitive deficiencies in senescence-accelerated mouse. │ Kor. J. Gerontol. │ 6 (2),14-21頁 (共著)
165.	1996/12	ラット脳内monoamine神経伝達系に対するtalipexoleの作用： Dopamine系を中心として │ 応用薬理 │ 52 (5),233-241頁 (共著)
166.	1996/11	In vivo induction of inducible nitric oxide synthase by microinjection with interferon-gamma and　lipopolysaccharide in rat hippocampus. │ Glia │ 18 (3),233-243頁 (共著)
167.	1996/11	Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons. │ J. Neurosci. Res. │ 46 (4),509-518頁 (共著)
168.	1996/10	Cyclic GMP elevation by 5-hydroxytryptamine in due to nitric oxide derived from endogenous nitrosothoil in NG108-15 cells. │ Biochem. Bioph. Res. Co. │ 227 (2),473-478頁 (共著)
169.	1996/07	Kyotorphin (L-tyrosyl-L-arginine) as a possible substrate for inducible nitric oxide synthase in rat glial cells. │ Neurosci. Lett. │ 212 (1),1-4頁 (共著)
170.	1996/06	Possible involvement of Janus kinase Jak2 in interferon- induction of nitric oxide synthase in rat glial cells. │ Eur. J. Pharmacol. │ 306 (1-3),297-306頁 (共著)
171.	1996/06	Senescence-accelerated mouse: Neurochemical studies on aging. │ Ann. NY Acad. Sci. │ 786,410-418頁 (共著)
172.	1996/03	Partial characterization of binding sites of VA-045, a novel apovincaminic acid derivative, in rat brain membranes. │ Gen. Pharmacol. │ 27 (2),279-284頁 (共著)
173.	1996/03	Regulation of [Ca²⁺]i rise activated by doxepin-sensitive H1-histamine receptors in Jurkat cells, cloned human T lymphocytes. │ Gen. Pharmacol. │ 27 (2),285-291頁 (共著)
174.	1996/01	Possible involvement of tyrosine kinase activation in　lipopolysaccharide-induced expression of Ca²⁺-insensitive but calmodulin-coupling nitric oxide synthase in rat glial cells. │ J. Neurosci. Res. │ (共著)
175.	1995/12	Acidic fibroblast growth factor protects memory and　immunoreactivity impairment in senescence accelerated mice. │ Neurobiology │ 3 (3-4),371-380頁 (共著)
176.	1995/04	Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus. │ NeuroReport │ 6 (16),2205-2208頁 (共著)
177.	1995/03	Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. │ Eur. J. Pharmacol. │ 289 (2),299-304頁 (共著)
178.	1995/03	Regulation of neuronal nitric oxide synthase in rat adrenal medulla. │ Hypertension │ 25 (3),431-346頁 (共著)
179.	1995/02	Biphasic effects of MPP⁺, a possible parkinsonism inducer, on dopamine content and tyrosine hydroxylase mRNA expression in PC12 cells. │ Neurochem. Int. │ 26 (2),165-171頁 (共著)
180.	1995/02	Inhibition by pentamidine on N-methyl-D-aspartate (NMDA) receptor/channels in the brain. │ Biol. Pharm. Bull. │ 18 (2),234-238頁 (共著)
181.	1995/01	Possible involvement of protein kinase C and low molecular weight GTP-binding proteins in thrombin-induced histamine secretion in human platelets. │ Biochem. Bioph. Res. Co. │ 206 (2),492-496頁 (共著)
182.	1994/11	1-Methyl-4-phenylpyridinium (MPP⁺)-induced cell death in PC12 cells: Inhibitory effects of several drugs. │ Neurochem. Int. │ 25 (5),419-424頁 (共著)
183.	1994/03	Suppressive effect of FK-506, a novel imunosuppressant, against MPTP-induced dopamine- depletion in the striatum of young C57BL/6 mice. │ J. Neuroimmunol. │ 50 (2),221-224頁 (共著)
184.	1994/01	抗てんかん薬 │ 薬局 │ 45 (1),49-54頁 (共著)
185.	1993/11	Inducible nitric oxide synthase in glial cells. │ Neurosci. Res. │ 18 (2),103-107頁 (共著)
186.	1993/07	Stimulatory effects of protein kinase C and calmodulin kinase II on NMDA receptor/channels in the postsynaptic density of rat brain. │ J. Neurochem. │ 61 (1),100-109頁 (共著)
187.	1993/05	Characterization of [³H]- staurosporine binding in protein kinase C-II purified from rat brain. │ Neurochem. Int. │ 22 (5),455-464頁 (共著)
188.	1993/03	Drugs acting on the intracellular signalling system. │ Med. Res. Rev. │ 13 (1),1-60頁 (共著)
189.	1993/03	Presence of m3 subtype muscarinic acetylcholine receptors and receptor-mediated increases in the cytoplasmic concentration of Ca²⁺ in Jurkat, a human leukemic helper T lymphocyte line. │ Mol. Pharmacol. │ 43 (3),356-364頁 (共著)
190.	1992/09	Glutamate inhibits adenylate cyclase activity in dispersed rat hippocampal cells directly via an N-methyl-D-aspartate-like metabotropic receptor. │ J. Neurochem. │ 59 (3),822-828頁 (共著)
191.	1992/04	Age-related changes in NMDA-induced [³H]-acetylcholine release from brain slices of senescence-accelerated mouse. │ Int. J. Dev. Neurosci. │ 10 (2),121-129頁 (共著)
192.	1992/03	Age-related changes in transmitter glutamate and NMDA receptor/channels in the brain of senescence-accelerated mouse. │ Neurosci. Lett. │ 137 (2),169-172頁 (共著)
193.	1991/10	Effects of antidepressants on the glutamatergic system in mouse brain. │ Neurochem. Int. │ 19 (3),247-253頁 (共著)
194.	1991/06	Effects of bifemelane hydrochloride, a brain function improver, on muscarinic receptors in the CNS of senescence-accelerated mouse. │ Jpn. J. Pharmacol. │ 56 (2),231-235頁 (共著)
195.	1991/05	Different effects of N-ethylmaleimide on the binding characteristics of 5-hydroxytryptamine receptor subtypes in rat brain membranes. │ Neurochem. Int. │ (共著)
196.	1991/04	脳情報伝達と加齢-細胞・分子機序- │ 蛋白質核酸酵素 │ 36 (4),723-729頁 (共著)
197.	1991/01	Effects of nebracetam (WEB1881FU), a novel nootropic, as a M1-muscarinic agonist. │ Jpn. J. Pharmacol. │ 55 (1),177-180頁 (共著)
198.	1990/08	Effects of sulfhydryl-modifying reagents, 3-nitro-2-pyridinesulfenyl compounds, on the coupling between inhibitory receptors and GTP-binding proteins Gi/Go in rat brain membranes. │ Mol. Pharmacol. │ 38 (2),184-191頁 (共著)
199.	1990/08	Possible involvement of different GTP-binding proteins in noradrenaline- and thrombin- stimulated release of arachidonic acid in rabbit platelets. │ Biochem. J. │ 270 (1),69-75頁 (共著)
200.	1990/04	Effects of WEB1881FU, a novel nootropic, on cholinergic and adrenergic receptors in the rat brain: action on M1-muscarinic receptors. │ Jpn. J. Pharmacol. │ 52 (4),597-607頁 (共著)
201.	1990/02	Involvement of glutamate receptor subtypes of L-[³H]noradrenaline release from cerebral cortical and hippocampal slices of mice. │ Neurochem. Int. │ 16 (1),11-16頁 (共著)
202.	1990/02	シナプス長期増強における逆行性伝達因子. │ 蛋白質核酸酵素 │ 35 (8),1477-1478頁 (単著)
203.	1989/12	Ligand-binding characteristics of [³H]QNB, [³H]prazosin, [³H]rauwolscine, [³H]TCP and [³H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse. │ Neurosci. Lett. │ 106 (3),334-338頁 (共著)
204.	1989/07	Ontogenesis of alpha2-adrenoceptor coupling with GTP-binding proteins in the rat telencephalon. │ J. Neurochem. │ 53 (1),249-257頁 (共著)
205.	1989/07	α2/β2キメラアドレナリン受容体とGi/GsキメラＧ蛋白-機能ドメインの解析. │ 実験医学 │ 7 (7),826-829頁 (共著)
206.	1989/04	Noradrenaline release enhanced by cholera toxin and pertussis toxin in rat cerebral cortical slices. │ J.Pharmacobio-Dyn. │ 12 (4),216-219頁 (共著)
207.	1988/09	Developmental changes in the levels of substrates for cholera toxin-catalyzed and pertussis toxin-catalyzed ADP-ribosylation in rat cardiac cell membranes. │ Jpn. J. Pharmacol. │ 48 (1),23-30頁 (共著)
208.	1988/09	脳α_２アドレノセプター系機構に関する分子薬理学的研究 │ 学位論文（薬学博士）北海道大学 │ (単著)
209.	1988/02	Effects of high KCl, isoproterenol, NaF and forskolin on noradrenaline release from cerebral cortical slices of adult and senescent rat. │ Neurochem. Int. │ 12 (1),13-17頁 (共著)
210.	1987/12	Uncoupling of rat cerebral cortical alpha2-adrenoceptors from GTP-binding proteins by N-ethylmaleimide. │ J. Neurochem. │ 49 (6),1984-1901頁 (共著)
211.	1987/02	Effects of pertussis toxin on the alpha2-adrenoceptor-inhibitory GTP-binding protein-adenylate cyclase system in rat brain: pharmacological and neurochemical studies. │ Eur. J. Pharmacol. │ 134 (2),123-130頁 (共著)
212.	1986/10	Enhancement of [³H]clonidine binding to rat cerebral synaptic membranes by treatment with arachidonic acid, prostaglandin (PG) D2, PGE2 and PGF2alpha. │ Jpn. J. Pharmacol. │ 42 (2),321-324頁 (共著)
213.	1986/10	杜仲葉の研究（1）水抽出画分の一般薬理作用. │ 和漢医薬学会誌 │ 3 (2),89-97頁 (共著)
214.	1986/07	Alpha2-adrenoceptor-GTP-binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent rats. │ Brain Res. │ 379 (1),118-124頁 (共著)
215.	1986/04	[³H]Clonidine and [³H]yohimbine binding to solubilized alpha2-adrenoceptors from rat cerebral cortex. │ Eur. J. Pharmacol. │ 123 (2),263-270頁 (共著)
216.	1985/11	Possible involvement of inhibitory GTP binding regulatory protein in alpha2-adrenoceptor-mediated inhibition of adenylate cyclase activity in cerebral cortical membranes of rats. │ J. Neurochem. │ 45 (5),1504-1508頁 (共著)
217.	1985/03	β-Adrnoceptor stimulation-induced increase in the number of α₂-adrenoceptors of cerebral cortical membranes in rats. │ Brain Res. │ 329 (1-2),259-264頁 (共著)
218.	1985/02	Decrease of clonidine binding affinity to α₂-adrenoceptor by ADP-ribosylation of 41,000-dalton proteins in rat cerebral cortical membranes by islet-activation protein. │ J. Neurochem. │ 44 (2),364-369頁 (共著)