研究者学術情報データベース

アマガセ　キクコ
天ヶ瀬　紀久子
AMAGASE KIKUKO

所属薬学部薬学科

職名教授

論文
1.	2024	Orally Administrated Glutamate Restored EAAT1 and 3 Expression Levels Suppressed in 5-Fluorouracil-damaged Intestinal Epithelial Cells │ (共著)
2.	2022/12	Efficacy of ginsenoside treatment to alleviate anticancer-drug induced mucoenteritis in mice │ Integrative Physiology │ 3,336-347頁 (共著)
3.	2022/12	Protective mechanisms of glutamine in intestinal diseases │ Integrative Physiology │ 3 (4),411-419頁 (共著)
4.	2022/08	Alleviative effects of glutamate against chemotherapeutic agent-induced intestinal mucositis. │ Journal of Physiology and Pharmacology │ 73 (4),539-546頁 (共著)
5.	2022/01	Investigation of the anti-inflammatory and analgesic activities of promising pyrazole derivative │ Eur J Pharm Sci │ 168,106080 (共著)
6.	2021/07	Protective effect of TRPM8 against indomethacin-induced small intestinal injury via the release of calcitonin gene-related peptide in mice. │ Biol. Pharm. Bull. │ 44,947-957頁 (共著)
7.	2021/01	Synthesis and Antimicrobial Activity of Some Novel 1,2-Dihydro-[1,2,4] triazolo[1,5-a]pyrimidines Bearing Amino Acid Moiety │ RSC Adv │ ,2905-2916頁 (共著)
8.	2020/12	Cytology-based detection of circulating tumour cells in human pancreatic cancer xenograft models with KRAS mutation │ Anticancer Res │ 40,6781-6789頁 (共著)
9.	2020/12	Role of Up-regulated Expression of ASIC3 in Sex Difference of Acid-Induced Duodenal HCO3-Responses. │ Curr Pharm Des │ 26,3001-3009頁 (共著)
10.	2020/06	Stimulation of Gastroduodenal HCO3- Secretion by Lubiprostone Mediated by Different Prostaglandin EP Receptor Subtypes │ Integrative　Physiology │ 1,92-100頁 (共著)
11.	2020/02	In vitro antioxidant and antimicrobial activities, and in vivo anti-inflammatory activity of crude and fractionated PHNQs from sea urchin (Evechinus chloroticus) │ Food Chem. │ 316,126339 (共著)
12.	2020/02	Leukotriene B4 receptor type 2 (BLT2) accelerates the healing of intestinal lesions by promoting epithelial cell proliferation │ Journal of Pharmacol. and Exp. Ther. │ 373,1-9頁 (共著)
13.	2018/07	Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus │ Am. J. Physiol. │ 315,G104-G116 (共著)
14.	2018/06	Roles of Cyclooxygenase, Prostaglandin E2 and EP Receptors in Mucosal Protection and Ulcer Healing in the Gastrointestinal Tract │ Curr. Pharm. Des. │ 24 (18),2002-2011頁 (共著)
15.	2018/03	Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P │ J. Pharmacol. Sci. │ 136,121-132 (共著)
16.	2018/01	Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis │ Br. J. Pharmacol. │ 175,84-99 (共著)
17.	2017/10	Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses │ Clin. Exp. Pharmacol. Physiol. │ 44,1017-1025 (共著)
18.	2017/09	Apoptosis, dysbiosis and expression of inflammatory cytokines are sequential events in the development of 5-fluorouracil-induced intestinal mucositis in mice │ Basic Clin. Pharmacol. Toxicol. │ 121,159-168 (共著)
19.	2017/09	G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells │ Pharmacol. Res. │ 123,27-39 (共著)
20.	2017/02	Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons │ J. Physiol. Pharmacol. │ 68,79-90 (共著)
21.	2017/01	NOX1/NADPH oxidase expressed in colonic macrophages contributes to the pathogenesis of colonic inflammation in trinitrobenzene sulfonic acid-induced murine colitis │ J. Pharmacol. Exp. Ther. │ 360,192-200 (共著)
22.	2017	Roles of prostaglandin E and EP receptors in mucosal protection and ulcer healing in the gastrointestinal trac │ Arch. Dig. Disord. │ 1,4-12 (共著)
23.	2016/12	スナネズミにおけるヘリコバクターピロリ誘起胃粘膜病変に対する大草胃腸薬の保護作用 │ 薬理と治療 │ 44,1733-1739 (共著)
24.	2016/06	5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis │ Br. J. Pharmacol. │ 173,1835-1849 (共著)
25.	2016/06	グルタミン酸の消化管粘膜保護薬としての可能性 │ 薬学雑誌 │ 135,779-782 (共著)
26.	2015/06	Regulatory mechanism of the gastric hyperemic response following barrier disruption: Roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons │ Curr. Pharm. Des. │ 21,1-10 (共著)
27.	2015/01	Saireito (TJ-114), a Japanese traditional herbal medicine, reduces 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells │ PLoS One │ 10,e0116213 (共著)
28.	2014/12	Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus │ Histochem. Cell Biol. │ 142,635-644 (共著)
29.	2014/12	Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats │ J. Gastroenterol. Hepatol. │ S4,37-46 (共著)
30.	2014/12	Importance of cyclooxygenase-1/prostacyclin in modulating gastric mucosal integrity under stress conditions │ J. Gastroenterol. Hepatol. │ S4,3-10 (共著)
31.	2014/08	ロキソプロフェン誘起小腸障害に対するプロバイオティクス製剤の効果 │ 薬理と治療 │ 42,581-589 (共著)
32.	2014/06	Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors │ J. Pharmacol. Exp. Ther. │ 349,470-479 (共著)
33.	2014/05	Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel -Prophylactic effect of antiulcer drugs- │ Curr. Pharm. Des. │ 20,1139-1148 (共著)
34.	2014/05	Prophylactic effect of monosodium glutamate on NSAID-Induced enteropathy in rats │ Curr. Pharm. Des. │ 20,2783-2790 (共著)
35.	2014/02	Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats │ J. Pharmacol. Exp. Ther. │ 348,227-235 (共著)
36.	2013	Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats │ J. Physiol. Pharmacol. │ 64,453-463 (共著)
37.	2013	Dual control of duodenal mucosal protection by cyclooxygenase (COX)-1 and COX-2 in cat │ J. Pharmacol. Exp. Ther. │ 344,189-195 (共著)
38.	2013	Effects of Helicobacter pylori infection on gastric parietal cells and E-cadherin in Mongolian gerbils │ J. Pharmacol. Sci. │ 121,305-311 (共著)
39.	2013	Irsogladine: Overview of the mechanisms of mucosal protective and healing-promoting actions in the gastrointestinal trac │ Curr. Pharm. Des. │ 19,106-114 (共著)
40.	2013	Prophylactic effect of egualen Na, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats │ J. Physiol. Pharmacol. │ 64,65-75 (共著)
41.	2013	Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats │ Life Sci. │ 93,441-447 (共著)
42.	2013	Serotonin 5-HT3 receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in mice intestinal crypt cells │ Br. J. Pharmacol. │ 168,1388-1400 (共著)
43.	2013	The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats │ Dig. Dis. Sci. │ 58,2840-2849 (共著)
44.	2012	Dual role of serotonin in the pathogenesis of indomethacin- induced small intestinal ulceration: Pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors │ Pharmacol. Res. │ 66,226-234 (共著)
45.	2012	Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: The role of intestinal motility │ J. Pharmacol. Exp. Ther. │ 343,270-277 (共著)
46.	2012	New therapeutic strategy for amino acid medicine: Prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy │ J. Pharmacol. Sci. │ 118,131-137 (共著)
47.	2012	NSAID起因性小腸損傷の発生−COX 阻害の病因論的役割− │ 日本薬理学雑誌 │ 139,103-108 (共著)
48.	2012	Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice │ Am. J. Physiol. │ 302,G1133-G1142 (共著)
49.	2012	Prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy. New therapeutic strategy for amino acid medicine │ J. Pharmacol. Sci │ 118,131-137頁
50.	2012	スナネズミにおけるHelicobacter pylori 誘起胃粘膜病変に対する御岳百草丸の保護作用 │ 薬理と治療 │ 40,413-420 (共著)
51.	2011	Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice │ Eur. J. Pharmacol. │ 650,411-417 (共著)
52.	2011	Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats │ J. Pharmacol. Exp. Ther. │ 338,850-859 (共著)
53.	2011	Carbon monoxide involved in modulating HCO3- secretion in rat duodenum │ J. Pharmacol. Exp. Ther. │ 337,293-300 (共著)
54.	2011	Dopamine D2-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating a7 nicotinic acetylcholine receptors │ J. Pharmacol. Sci. │ 116,274-282 (共著)
55.	2011	Gastric ulcerogenic and healing impairment actions of alendronate, a nitrogen-containing bisphosphonate: Prophylactic effects of rebamipide │ Curr. Pharm. Des. │ 17,1602-1611 (共著)
56.	2011	Gastric ulcerogenic and healing impairment effects of risedronate, a nitrogen-containing bisphosphonate, in rats: Comparison with alendronate and minodronate │ J. Physiol. Pharmacol. │ 62,609-618 (共著)
57.	2011	NSAIDのピットフォール. 薬剤性潰瘍の実態と対応: 低用量アスピリン、NSAIDを中心に │ 実験治療 │ 701,20-24 (共著)
58.	2011	Role of macrophage colony-stimulating factor (M-CSF)-dependent macrophages in gastric ulcer healing in mice │ J. Physiol. Pharmacol. │ 62,441-448 (共著)
59.	2011	グルタミン酸による消化管粘膜保護作用 │ 薬学雑誌 │ 131,1711-1719 (共著)
60.	2011	α7ニコチン性アセチルコリン受容体. 最近注目されている消化管の受容体 │ G.I.Research │ 19,49-56 (共著)
61.	2011	胃酸および十二指腸アルカリ分泌調節におけるムスカリン受容体サブタイプ4の重要性. 特集最近注目されている消化管の受容体 │ G.I.Research │ 19,17-23 (共著)
62.	2010	Acetic acid ulcer model: State of the arts in 2010 │ Polish Gastroenterol. │ 17,165-168 (共著)
63.	2010	Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors │ J. Gastroenterol. Hepatol. │ 25,S67-S74 (共著)
64.	2010	New frontiers in gut nutrient sensor research: Prophylactic effect of glutamine against helicobacter pylori-induced gastric diseases in mongolian gerbils │ J. Pharmacol. Sci. │ 112,25-32 (共著)
65.	2010	New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin │ J. Gastroenterol. Hepatol. │ 25,S15-S22 (共著)
66.	2010	Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats through induction of heme oxygenase-1 │ J. Physaiol. Pharmacol. │ 61,287-294 (共著)
67.	2010	Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity │ J. Pharmacol. Sci. │ 114,248-261 (共著)
68.	2010	Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats │ J. Gastroenterol. Hepatol. │ 25,S111-S118 (共著)
69.	2010	Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage │ Clin. Chim. Acta │ 411,459-466 (共著)
70.	2010	The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease │ Clin. Exp. Immunol. │ 160,386-393 (共著)
71.	2010	Urocortin prevents indomethacin-induced small intestinal lesions in rats through activation of CRF2 receptors │ Dig. Dis. Sci. │ 55,1570-1580 (共著)
72.	2010	アスピリン潰瘍の発症機序とその特徴 │ 日本臨床 │ 68,1962-1965 (共著)
73.	2010	胃粘膜防御薬イルソグラジンマレイン酸塩のAspirin誘起ラット小腸損傷に対する予防効果 │ 薬理と治療 │ 38,297-302 (共著)
74.	2009	Aggravation of cold-restraint stress-induced gastric lesions in adjuvant arthritic rats: Pathogenic role of inducible and endothelial nitric oxide │ J. Pharmacol. Sci. │ 111,244-252 (共著)
75.	2009	Helicobacter pylori感染と低用量アスピリンによる胃粘膜傷害”. 動物実験におけるアスピリン胃粘膜傷害 │ Helicobacter Research │ 13,117-122 (共著)
76.	2009	Impairment by 5-fluorouracil of the healing of gastric lesions in rats: Effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons │ Dig. Dis. Sci. │ 54,36-45 (共著)
77.	2009	Prevention of NSAID-induced small intestinal mucosal injury: Prophylactic potential of lansoprazole │ J. Clin. Biochem. Nutr. │ 45,58-63 (共著)
78.	2009	高齢者とNSAIDs惹起性消化管傷害”. アスピリンによる胃粘膜傷害の発生機序 │ 老年消化器病 │ 21,31-36 (共著)
79.	2009	新消化管の分子生物学第6回. 消化管カプサイシン感受性知覚神経の分子生物学 │ G.I. Research │ 17,361-366 (共著)
80.	2009	非ステロイド性抗炎症薬(NSAID)誘起小腸傷害の病態生理:関節炎発症時における小腸障害の増悪 │ 日薬理誌 │ 133,203-205 (共著)
81.	2008	Contribution of glucocorticoids to protective influence of preconditioning mild stress against stress-induced gastric erosions │ Ann. N.Y. Acad. Sci. │ 1148,209-212 (共著)
82.	2008	Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats │ Dig. Dis. Sci. │ 53,2657-2666 (共著)
83.	2008	Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis │ Gastroenterology │ 134,215-225 (共著)
84.	2008	消化管粘膜防御製剤の新たな可能性を求めて. インドメタシン誘起小腸傷害に対するテプレノンの有用性 │ 消化器の臨床 │ 11,31-36 (共著)
85.	2007	Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors │ Am. J. Phisiol. │ 293,G788-G797 (共著)
86.	2007	Dual action of nitric oxide in the pathogenesis of ischemia/reperfusion -induced mucosal injury in mouse stomach │ Digestion │ 75,188-197 (共著)
87.	2007	Effect of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy) benzamido) ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa │ J. Pharmacol. Exp. Ther. │ 322,903-912 (共著)
88.	2007	Effect of dopamine on the healing of acetic acid-induced gastric ulcers in rats │ Inflammopharmacology │ 15,209-213 (共著)
89.	2007	Helicobacter pylori誘起胃粘膜病変に対するグルタミンおよびマーズレンの保護作用 │ 薬理と治療 │ 35,479-488 (共著)
90.	2007	Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats │ Dig. Dis. Sci. │ 52,1879-1889 (共著)
91.	2007	Increased susceptibility of small intestine to NSAID-provoked ulceration in rats with adjuvant-induced arthritis: involvement of enhanced expression of TLR4 │ Life Sci. │ 81,1309-1316 (共著)
92.	2007	NSAID誘起消化管障害におけるCOX阻害の意義 ”NSAID起因性消化管病変 │ G.I. Research │ 5,455-463 (共著)
93.	2007	Pathogenic importance of pepsin in ischemia/reperfusion-induced gastric injury │ Life Sci. │ 80,1984-1992 (共著)
94.	2007	Prophylactic effect of rebamipide against the irritative and healing impairment actions of alendronate in rat stomachs │ Inflammopharmacology │ 15,196-202 (共著)
95.	2007	アレンドロネート誘起胃幽門洞損傷に対するマレイン酸イルソグラジンの効果 │ 薬理と治療 │ 35,587-599 (共著)
96.	2007	抗癌剤5-フルオロウラシル (5-FU) による急性胃粘膜損傷の治癒遅延：ヒスタミンH2受容体拮抗薬ラフチジンの知覚神経を介した改善作用 │ 薬理と治療 │ 35,459-468 (共著)
97.	2006	Gastro-intestinal patch system for the delivery of erythropoietin │ J. Control. Release │ 111,19-26 (共著)
98.	2006	Roles of Cyclooxygenase-2 and prostacyclin/IP receptors in mucosal defense against ischemia/reperfusion injury in mouse stomach │ J. Pharmacol. Exp. Ther. │ 316,547-555 (共著)
99.	2006	アレンドロネートによる胃粘膜障害の発生および潰瘍の治癒遅延に対するレバミピドの影響 │ 薬理と治療 │ 34,305-316 (共著)
100.	2006	プロスタグランジンの消化管粘膜保護作用とEP受容体サブタイプ．サイトプロテクション-生体防御機構の解明と最先端医療への道- │ 癌と化学療法 │ ,61-70 (共著)
101.	2005	A novel gastric lesion model induced in rats by partial gastric vascular ligation │ Inflammopharmacology │ 13,261-272 (共著)
102.	2005	Absorption of interferon alpha from patches in rats │ J. Drug Target. │ 13,383-390 (共著)
103.	2005	An overview of acetic acid ulcer models --the history and state of the art of peptic ulcer research │ Biol. Pharm. Bull. │ 28,1321-1341 (共著)
104.	2004	消化性潰瘍治癒のメカニズム−胃潰瘍治癒の質にかかわる因子 │ 医学のあゆみ │ 210,1707-1711 (共著)
105.	2003	Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats │ J. Physiol. Pharmacol. │ 54,349-360 (共著)
106.	2003	On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion │ J. Pharmacol. Sci. │ 92,124-136 (共著)
107.	2003	Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and futur │ Pharmacol. Ther. │ 98,109-127 (共著)
108.	2003	消化性潰瘍の治癒機構および治療薬の開発に対する考案1）酢酸潰瘍モデルの考案と薬効評価を中心にして │ 日薬理誌 │ 122,73-92 (共著)
109.	2002	Acetic acid ulcers : a new method for producing solitary chronic ulcers in rat stomachs by intraluminal application of acetic acid solution │ Inflammopharmacology │ 10,385-389 (共著)
110.	2002	Protective effect of roxatidine for taurocholate-induced cell damage in RGM-1 cells: Involvment of a 70 k-Da heat shock protei │ J. Dig. Protec. │ 3,9-17 (共著)
111.	2001	Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats │ J. Physiol. Pharmacol. │ 52,391-406 (共著)
112.	2001	Pharmacological regulation of gastric acid secretion in the apical membrane of parietal cells : A new target for antisecretory drugs │ J. Physiol. Pharmacol. │ 52,639-656 (共著)
113.	1999	A new ulcer model, "unhealed gastric ulcers", induced by chronic treatment with indomethacin in rats with acetic acid ulcers │ J. Physiol. Pharmacol. │ 50,169-181 (共著)
114.	1999	Antisecretory and ulcer healing effects of S-0509, a novel CCK-B/gastrin receptor antagonist, in rats │ Dig. Dis. Sci. │ 44,879-888 (共著)
115.	1999	シメチジンおよびセトラキサート配合薬（DH4701）のラット急性胃損傷の発生および基礎胃酸分泌に対する効果 │ Ther. Res. │ 20,189-197 (共著)
116.	1997	消化酵素ビオジアスターゼ2000およびプロザイム6のラット慢性胃潰瘍の治癒に対する影響 │ Ther. Res. │ 18,259-265 (共著)
117.	1996	Effects of the novel histamine H2-receptor antagonist (±)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5-(methylamino) methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine on gastric secretion and gastroduodenal ulcers in rats │ Arzneimittelforschung │ 46,177-184 (共著)
118.	1996	Vasoinhibitory effect of leminoprazole, a H+, K+-ATPase inhibitor, on rat aortic rings │ Gen. Pharmacol. │ 27,117-121 (共著)
119.	1996	メチルメチオニンスルホニウムクロライド（MMSC）のラット胃粘膜細胞に対する保護作用について │ Ther. Res. │ 17,343-349 (共著)