Researcher Database

IZUMIKAWA TOMOMI

Department / Course College of Pharmaceutical Sciences Department of Pharmaceutical Sciences

Title / Position Assistant Professor

Papers
1.	2023/09	Chondroitin sulfate is required for follicle epithelial integrity and organ shape maintenance in Drosophila. │ Development (Cambridge, England) │ 150 (17)
2.	2023/04	Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe. │ Journal of cell science │ 136 (7)
3.	2019	Enhanced hexosamine metabolism drives pro-tumorigenic signaling pathways involving hyaluronan and O-GlcNAcylation in aggressive breast cancer. │ Cell Death & Disease │ 10 (11),pp.803
4.	2019	Regulatory Mechanism of 2-O-Phosphorylation of Xylose in the Glycosaminoglycan-Linkage Region of the Tetrasaccharide, │ Trends in Glycoscience and Glycotechnology │ ,pp.E57-E62
5.	2018	Metabolic Reprogramming and Hyaluronan Production in Cancer Stem Cells │ Trends in Glycoscience and Glycotechnology │ ,pp.E147-E154
6.	2017	Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling │ Journal of Cell Biology │ 216,pp.2911-2926
7.	2016	Chondroitin 4-O-Sulfotransferase Is Indispensable for Sulfation of Chondroitin and Plays an Important Role in Maintaining Normal Life Span and Oxidative Stress Responses in Nematodes │ Journal of Biological Chemistry │ 291,pp.23294-23304
8.	2016	Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism; association with progression of multiple sclerosis │ Neuroscience Research │ 108,pp.55-59
9.	2016	Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling │ Journal of Biological Chemistry │ 291,pp.24105-24120
10.	2015	A sulfated glycosaminoglycan linkage region is a novel type of Human Natural Killer-1 (HNK-1) epitope expressed on aggrecan in perineuronal nets │ PLoS ONE │ 10,pp.e0144560
11.	2015	Amino acid sequence surrounding the chondroitin sulfate attachment site of thrombomodulin regulates chondroitin polymerization │ Biochemical and Biophysical Research Communications │ 460,pp.233-237
12.	2015	GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1. │ Journal of Biological Chemistry │ 290,pp.5438-5448
13.	2015	Processing by Convertases Is Required for Glypican-3-induced Inhibition of Hedgehog Signaling. │ Journal of Biological Chemistry │ 290,pp.7576-7585
14.	2014	Chondroitin Sulfate Is Indispensable for Pluripotency and Differentiation of Mouse Embryonic Stem Cells │ Scientific Reports │ 4,pp.3701
15.	2014	Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans │ Journal of Biological Chemistry │ 289,pp.6695-6708
16.	2013	A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1. │ Biochimica et Biophysica Acta │ 1830,pp.4806-4812
17.	2012	Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1 │ Biochemical Journal │ 441,pp.697-705
18.	2012	Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to N-cadhrin and cadherin-11 │ Biochemical and Biophysical Research Communications │ 420,pp.523-529
19.	2011	Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin N-acetylgalactosaminyltransferase-2 │ Biochemical Journal │ 434,pp.321-331
20.	2011	Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies │ Journal of Human Genetics │ 56,pp.143-146
21.	2011	Correlation of C4ST-1 and CnGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis │ Biochemical and Biophysical Research Communications │ 406,pp.36-41
22.	2011	Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin │ Biochemical and Biophysical Research Communications │ 415,pp.109-113
23.	2010	Chondoroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development │ Biochemical Journal │ 432,pp.47-55
24.	2010	Glycosaminoglycans in Development, Health and Disease Mice deficient in glucuronyltransferase-I. │ Elsevier │ ,pp.19-34
25.	2010	Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I-deficient mice │ Journal of Biological Chemistry │ 285,pp.12190-12196
26.	2010	Two Golgi-resident 3'-phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans │ Journal of Biological Chemistry │ 285,pp.24717-24728
27.	2009	FAM20B is a Kinase that Phosphorylates Xylose in the Glycosaminoglycan-Protein Linkage Region │ Biochemical Journal │ 421,pp.157-162
28.	2008	2-O-phosphorylation of xylose and 6-O-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage regions synthesis │ Journal of Biological Chemistry │ 283,pp.16801-16807
29.	2008	Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: Chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members │ Journal of Biological Chemistry │ 283,pp.11396-11406
30.	2007	Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis │ Journal of Biological Chemistry │ 282,pp.8533-8544
31.	2007	Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin polymerizing factor │ Biochemical Journa │ 40,pp.545-552
32.	2006	C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans │ Developmental Biology │ 296,pp.409-420
33.	2006	Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity │ Journal of Biological Chemistry │ 281,pp.38668-38674
34.	2006	Essential roles of 3'-phosphoadenosine 5'-phoshosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans │ Journal of Biological Chemistry │ 281,pp.11431-11440
35.	2006	Heparan sulfate polymerization in Drosophila │ Journal of Biological Chemistry │ 281,pp.1929-1934
36.	2004	Nematode chondroitin polymerizing factor showing cell/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division │ Journal of Biological Chemistry │ 279,pp.53755-53761
37.	2003	Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization │ Journal of Biological Chemistry │ 278,pp.23666-23671