研究者学術情報データベース

キヨズミ　ダイジ
淨住　大慈
KIYOZUMI DAIJI

所属総合科学技術研究機構

職名准教授

論文
1.	2020/06/05	NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility │ Science │ 368 (6495),1132-1135頁
2.	2023/04/24	A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility │ Nature Communications │ 14 (1),2354
3.	2025/07	Chemical Synthesis of NICOL, A Coligand Secreted Protein Mediating Mammalian Male Reproductive Tract Trans-luminal Signaling │ Chemistry - A European Journal │
4.	2024/01/02	Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract │ Reproductive Biology and Endocrinology │ 22 (1),3
5.	2024/04/10	Distinct actions of testicular endocrine and lumicrine signaling on the proximal epididymal transcriptome │ Reproductive Biology and Endocrinology │ 22 (1),40
6.	2025	CRISPR/Cas9‐mediated genome editing reveals seven testis‐enriched transmembrane glycoproteins dispensable for male fertility in mice │ Andrology │ 13,1251-1260頁
7.	2024/05/21	Gene-deficient mouse models established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility │ Frontiers in Cell and Developmental Biology │ 12 (1),1411162-1411162頁
8.	2024/03	プロテオリシスを介した精子成熟メカニズムの解明 │ 日本応用酵素協会誌 │ 58,35-37頁
9.	2024/02/09	Busulfan administration replicated the characteristics of the epididymal initial segment observed in mice lacking testis-epididymis lumicrine signaling │ Journal of Reproduction and Development │ 70 (2),104-114頁
10.	2023/11	Lumicrine signaling: Extracellular regulation of sperm maturation in the male reproductive tract lumen │ Genes to Cells │ 28 (11),757-763頁
11.	2023/11	New insights into lumicrine secreted signalling that regulates the function of the mammalian male reproductive tract │ Developmental Biology │ 503,111-112頁
12.	2023/11	ルミクリンシグナル伝達：精巣に由来する分泌因子による精巣上体分化と精子成熟の制御 │ Reproductive Immunology and Biology │ 38,10-17頁
13.	2023/08/02	ADGRG2 is dispensable for lumicrine signalling regulating epididymal initial segment differentiation and gene expression │ Biology of reproduction │ 109 (4),474-481頁
14.	2022/09/07	The molecular mechanisms of mammalian sperm maturation regulated by NELL2-ROS1 lumicrine signaling. │ Journal of Biochemistry │ 172 (6),341-346頁
15.	2022/08	精子の成熟機構をオンにする分子「NELL2」―ルミクリンシグナル伝達機構の解明 │ 生化学 │ 94 (4),560-564頁
16.	2022/05/04	Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies │ Frontiers in Endocrinology │ 13,876370-876370頁
17.	2022/01	精子の成熟機構と受精能 │ ファルマシア │ 58 (1),18-23頁
18.	2021/08/06	Human disease-associated extracellular matrix orthologs ECM3 and QBRICK regulate primary mesenchymal cell migration in sea urchin embryos. │ Experimental Animals │ 70 (3),378-386頁
19.	2020/10	新規なシグナル伝達システム「ルミクライン」による雄性生殖路の機能と妊孕性の制御 │ 実験医学 │ 38 (18),3132-3135頁
20.	2020/10	精子が「一人前」になる仕組み – 「ルミクライン因子」が司る精子成熟の分子メカニズムに迫る │ academist Journal │
21.	2020/08	精子が受精能をもつための鍵分子を発見！ │ 化学 │ 75,75-75頁
22.	2020/03/28	CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice │ Cells │ 9 (4),E821
23.	2020	Genetic mutation of Frem3 does not cause fraser syndrome in mice │ Experimental Animals │ 69 (1),104-109頁
24.	2020	Laminin is the ECM niche for trophoblast stem cells │ Life Science Alliance │ 3 (2),e201900515
25.	2019/08/01	CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice │ Biology of Reproduction │ 101 (2),501-511頁
26.	2019/01/01	Ventricular–subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche │ Molecular Biology of the Cell │ 30 (1),56-68頁
27.	2019	Lvrn expression is not critical for mouse placentation │ Journal of Reproduction and Development │ 65 (3),239-244頁
28.	2018	Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality. │ Life science alliance │ 1 (5),e201800064
29.	2017/11	Placenta-specific gene manipulation using lentiviral vector and its application │ Placenta │ 59,S37-S43頁
30.	2016/07/12	Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice │ Proceedings of the National Academy of Sciences of the United States of America │ 113 (28),7704-7710頁
31.	2016/02	Functional analysis of Plac1 in placental formation using knockout mice and lentiviral vector-mediated complementation │
32.	2016/01/01	Lentiviral vector-mediated complementation restored fetal viability but not placental hyperplasia in Plac1-deficient mice │ Biology of Reproduction │ 94 (1),6
33.	2014	In situ detection of integrin ligands │ Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] │ 65,10.19.1-10.19.17頁
34.	2014	In situ detection of integrin ligands │ Current Protocols in Cell Biology │ 2014,9.7.1-9.7.17頁
35.	2013/07/09	GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development │ PLoS ONE │ 8 (7),e68781
36.	2012/07/20	Polydom/SVEP1 is a ligand for integrin α9β1 │ Journal of Biological Chemistry │ 287 (30),25615-25630頁
37.	2012/05	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins │ Journal of Cell Biology │ 197 (5),677-689頁
38.	2011/09	Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice │ PLoS Genetics │ 7 (9),e1002278
39.	2011/07/29	Fused pulmonary lobes is a rat model of human Fraser syndrome │ Biochemical and Biophysical Research Communications │ 411 (2),440-444頁
40.	2011/07	Identification of genes expressed during hair follicle induction │ Journal of Dermatology │ 38 (7),674-679頁
41.	2010/04	Genetic analysis of fin development in zebrafish identifies furin and Hemicentin1 as potential novel fraser syndrome disease genes │ PLoS Genetics │ 6 (4),e1000907
42.	2008/09/02	Transcriptome-based systematic identification of extracellular matrix proteins │ Proceedings of the National Academy of Sciences of the United States of America │ 105 (35),12849-12854頁
43.	2007/07	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1 │ Matrix Biology │ 26 (6),456-462頁
44.	2007/06	基底膜のカスタマイゼーションとその器官形成における役割 │ THE LUNG perspective │ 15 (3),336-340頁
45.	2006/11	Reciprocal stabilization of Fraser syndrome-associated proteins │ MATRIX BIOLOGY │ 25,S81-S81頁
46.	2006/08/08	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects │ Proceedings of the National Academy of Sciences of the United States of America │ 103 (32),11981-11986頁
47.	2005/05/15	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle │ Experimental Cell Research │ 306 (1),9-23頁
48.	2005/02/01	Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis │ Experimental Cell Research │ 303 (1),148-159頁
49.	2002	Pollen UDP-glucose pyrophosphorylase showing polymorphism well-correlated to the S genotype of Pyrus pyrifolia │ Sexual Plant Reproduction │ 14 (6),315-323頁